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MMP9抗體,Mouse Monoclonal MMP9 Antibody
  • MMP9抗體,Mouse Monoclonal MMP9 Antibody
  • MMP9抗體,Mouse Monoclonal MMP9 Antibody
  • MMP9抗體,Mouse Monoclonal MMP9 Antibody

MMP9抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-09
QQ交談 微信洽談

產品詳情

中文名稱:MMP9抗體英文名稱:Mouse Monoclonal MMP9 Antibody
品牌: 艾普蒂產地: 武漢
保存條件: Stored at -20°C for 432 year. Avoid repeated freeze / thaw cycles.產品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點: MMP9
2025-05-09 MMP9抗體 Mouse Monoclonal MMP9 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 432 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術 Human,Mouse,Rat
IF咨詢技術 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產品詳情

AliasesGELB; CLG4B; MMP-9; MANDP2
Entrez GeneID4318
clone5G3
WB Predicted band size92kDa
Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat,Rabbit,Monkey
ImmunogenPurified recombinant fragment of human MMP9 expressed in E. Coli.  
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);    


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       Immunofluorescence analysis of NIH/3T3 cells using MMP9 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Flow cytometric analysis of Hela cells using MMP9 mouse mAb (blue) and negative control (red).    


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       Flow cytometric analysis of Hela cells using MMP9 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of  COS7 cells using MMP9 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of  C6 cells using MMP9 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of  NIH/3T3 cells using MMP9 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human brain tissues using MMP9 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rat cerebellum using MMP9 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rabbit brain using MMP9 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rabbit rectum using MMP9 mouse mAb with DAB staining.    


           

參考文獻

以下是3篇與MMP9抗體相關的代表性文獻及其摘要概括:

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1. **"MMP-9 Antibody Inhibition of Tumor Growth and Invasion in a Novel Model of Metastatic Breast Cancer"**

*作者:Hua H. et al. (2011)*

**摘要**:研究通過特異性MMP-9抗體阻斷MMP-9活性,顯著抑制乳腺癌細胞的侵襲和轉移,表明MMP-9抗體在治療轉移性腫瘤中的潛在應用價值。

2. **"Localization of Matrix Metalloproteinase 9 (MMP-9) in Atherosclerotic Plaques by Immunohistochemistry"**

*作者:Galis Z.S. et al. (1994)*

**摘要**:利用MMP-9抗體進行免疫組化分析,發(fā)現(xiàn)動脈粥樣硬化斑塊中MMP-9高表達,提示其在血管重塑和斑塊破裂中的關鍵作用。

3. **"Role of MMP-9 in Blood-Brain Barrier Breakdown Following Ischemic Stroke"**

*作者:Rosenberg G.A. et al. (1998)*

**摘要**:通過MMP-9抗體檢測發(fā)現(xiàn),缺血性中風后腦組織中MMP-9水平升高,與血腦屏障破壞直接相關,為中風治療提供新靶點。

4. **"Targeting MMP-9 in Inflammatory Diseases: Therapeutic Perspectives of Antibody-Based Approaches"**

*作者:Vandooren J. et al. (2013)*

**摘要**:綜述探討MMP-9在炎癥性疾病中的作用,并系統(tǒng)分析MMP-9抗體在類風濕性關節(jié)炎、慢性潰瘍等疾病中的治療潛力及挑戰(zhàn)。

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以上文獻覆蓋了腫瘤、心血管疾病、神經系統(tǒng)疾病及炎癥領域,展示了MMP9抗體在基礎研究和臨床應用的多樣性。如需具體文獻鏈接或補充信息,可進一步說明。

       

背景信息

Matrix metalloproteinase 9 (MMP9), a member of the zinc-dependent endopeptidase family, plays a critical role in extracellular matrix (ECM) remodeling by degrading components like collagen IV and gelatin. It is implicated in physiological processes (tissue repair, angiogenesis) and pathological conditions, including cancer metastasis, chronic inflammation, and cardiovascular diseases. MMP9 is secreted as an inactive zymogen (pro-MMP9) and activated through proteolytic cleavage, regulating cellular migration and signaling pathways.

MMP9 antibodies are essential tools for detecting and quantifying MMP9 expression in research and diagnostics. These antibodies target specific epitopes, such as the catalytic domain or hemopexin-like region, enabling applications in Western blotting, immunohistochemistry (IHC), and ELISA. Monoclonal antibodies offer high specificity, while polyclonal antibodies may detect multiple isoforms or cleavage forms. Validation ensures recognition of both pro- and active MMP9 forms, critical for studying its regulation in diseases.

In cancer research, MMP9 antibodies help assess tumor invasiveness and prognosis. In inflammatory diseases, they monitor MMP9's role in tissue damage. Clinically, MMP9 is explored as a biomarker for conditions like atherosclerosis or rheumatoid arthritis. Therapeutic MMP9 inhibitors are under investigation, though none are approved, highlighting the antibody's continued relevance in mechanistic and translational studies.

       
關鍵字: MMP9抗體;MMP9;MMP9 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學、質量管理體系。并不斷致力于技術創(chuàng)新,產品創(chuàng)新和管理創(chuàng)新,贏得了國內外廣大用戶的信任。
成立日期 2024-06-24 (3年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內
主營行業(yè) 中間體,化學試劑 經營模式 貿易,工廠,試劑,定制,服務
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:3年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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