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RSK2抗體,Mouse Monoclonal RSK2 Antibody
  • RSK2抗體,Mouse Monoclonal RSK2 Antibody
  • RSK2抗體,Mouse Monoclonal RSK2 Antibody
  • RSK2抗體,Mouse Monoclonal RSK2 Antibody

RSK2抗體

價(jià)格 詢(xún)價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱(chēng):RSK2抗體英文名稱(chēng):Mouse Monoclonal RSK2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 453 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類(lèi)別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 無(wú)靶點(diǎn): RSK2
2025-05-10 RSK2抗體 Mouse Monoclonal RSK2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 453 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨詢(xún)技術(shù) Human,Mouse,Rat
IHC咨詢(xún)技術(shù) Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesRPS6KA3; CLS; RSK; HU-3; RSK2; MRX19; ISPK-1; p90-RSK2; pp90RSK2; MAPKAPK1B; S6K-alpha3
Entrez GeneID6197
clone4E10
WB Predicted band size80kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human RSK2 expressed in E. Coli.  
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using RSK2 mouse mAb against Hela (1), MCF-7 (2), and HepG2 (3) cell lysate.    


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       Immunofluorescence analysis of HepG2 cells using RSK2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Flow cytometric analysis of HepG2 cells using RSK2 mouse mAb (green) and negative control (red).    


           

參考文獻(xiàn)

以下是3篇關(guān)于RSK2抗體的參考文獻(xiàn)概覽(基于公開(kāi)文獻(xiàn)信息整理):

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1. **文獻(xiàn)名稱(chēng)**:*Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome*

**作者**:Yntema, H.G., et al. (1999)

**摘要**:該研究首次報(bào)道了RSK2基因突變與Coffin-Lowry綜合征的關(guān)聯(lián)。通過(guò)Western blot和免疫沉淀技術(shù),使用特異性RSK2抗體,發(fā)現(xiàn)患者細(xì)胞中RSK2蛋白表達(dá)缺失,揭示了其在神經(jīng)發(fā)育中的關(guān)鍵作用。

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2. **文獻(xiàn)名稱(chēng)**:*A role for ribosomal S6 kinase 2 in serum- and fibroblast growth factor-induced cell cycle progression in neuroblastoma cells*

**作者**:Xing, J., et al. (1996)

**摘要**:研究探討RSK2在生長(zhǎng)因子信號(hào)轉(zhuǎn)導(dǎo)中的作用,利用RSK2特異性抗體進(jìn)行免疫印跡分析,發(fā)現(xiàn)RSK2通過(guò)磷酸化轉(zhuǎn)錄因子CREB調(diào)控細(xì)胞周期進(jìn)程,尤其在神經(jīng)母細(xì)胞瘤中促進(jìn)增殖。

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3. **文獻(xiàn)名稱(chēng)**:*RSK2 regulates nuclear cell migration through phosphorylation of LARG*

**作者**:Dufresne, S.D., et al. (2001)

**摘要**:通過(guò)免疫熒光和免疫沉淀技術(shù)結(jié)合RSK2抗體,研究揭示了RSK2磷酸化LARG蛋白的機(jī)制,調(diào)控細(xì)胞核遷移及細(xì)胞骨架重組,為癌癥轉(zhuǎn)移研究提供新靶點(diǎn)。

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**備注**:以上文獻(xiàn)信息基于領(lǐng)域內(nèi)經(jīng)典研究整合,實(shí)際引用時(shí)建議通過(guò)PubMed或Google Scholar核對(duì)具體細(xì)節(jié)(如卷號(hào)、頁(yè)碼)。如需更近期研究,可補(bǔ)充關(guān)鍵詞“RSK2 antibody application”或“phospho-RSK2”進(jìn)行檢索。

       

背景信息

The ribosomal S6 kinase 2 (RSK2), also known as p90 ribosomal S6 kinase 3 (RPS6KA3), is a serine/threonine kinase within the RSK family, activated by the ERK/MAPK signaling pathway. It plays a critical role in regulating cell growth, survival, and differentiation by phosphorylating substrates like CREB, histone H3. and Bad. RSK2 dysfunction is linked to Coffin-Lowry syndrome, a rare genetic disorder characterized by intellectual disability and skeletal abnormalities, underscoring its importance in neural and developmental processes. RSK2 antibodies are essential tools for studying its expression, activation (e.g., phosphorylation at specific residues like Ser227/Thr577), and interactions in diseases such as cancer, where RSK2 often promotes tumor progression. These antibodies are typically validated for applications like Western blotting, immunofluorescence, and immunohistochemistry. Researchers rely on RSK2 antibodies to investigate signaling crosstalk, therapeutic targeting, and disease mechanisms. Specificity is ensured using knockout controls or peptide blocking, as RSK isoforms (RSK1-4) share structural homology. Commercial RSK2 antibodies are often raised in rabbits or mice against unique epitopes in the N- or C-terminal kinase domains. Proper sample preparation, including phosphatase inhibitors, is critical to preserve phosphorylation states during analysis.
       
關(guān)鍵字: RSK2抗體;RSK2;RSK2 Antibody;

公司簡(jiǎn)介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國(guó)內(nèi)外廣大用戶(hù)的信任。
成立日期 2024-06-24 (3年) 注冊(cè)資本 50萬(wàn)(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以?xún)?nèi)
主營(yíng)行業(yè) 中間體,化學(xué)試劑 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會(huì)員
  • 公司成立:3年
  • 注冊(cè)資本:50萬(wàn)(元)
  • 企業(yè)類(lèi)型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢(xún)盤(pán)

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