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GPC3抗體,Mouse Monoclonal GPC3 Antibody
  • GPC3抗體,Mouse Monoclonal GPC3 Antibody
  • GPC3抗體,Mouse Monoclonal GPC3 Antibody
  • GPC3抗體,Mouse Monoclonal GPC3 Antibody

GPC3抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:GPC3抗體英文名稱:Mouse Monoclonal GPC3 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 518 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點: GPC3
2025-05-10 GPC3抗體 Mouse Monoclonal GPC3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 518 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesSGB; DGSX; MXR7; SDYS; SGBS; OCI-5; SGBS1; GTR2-2
Entrez GeneID2719
clone9C2
WB Predicted band size65.5kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenPurified recombinant fragment of human GPC3 expressed in E. Coli.  
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using GPC3 mouse mAb against HepG2 (1), HEK293 (2), Jurkat (3), SK-N-SH (4), PC-12 (5), F9 (6)and Mouse liver (7) cell lysate.    


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       Flow cytometric analysis of Jurkat cells using GPC3 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of NIH/3T3 cells using GPC3 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of C6 cells using GPC3 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using GPC3 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human breast cancer tissues using GPC3 mouse mAb with DAB staining.    


           

參考文獻

以下是3篇關(guān)于GPC3抗體的參考文獻概覽(信息基于公開研究數(shù)據(jù)整理,具體文獻請核實原文):

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1. **文獻名稱**:"A human single-domain antibody elicits potent antitumor activity by targeting an epitope in mesothelin and glypican-3"

**作者**:Yamaguchi T, et al.

**摘要**:報道了一種靶向GPC3和間皮素的雙特異性單域抗體(HN3),通過阻斷Wnt/YAP信號通路抑制腫瘤生長,并在肝癌小鼠模型中顯示出顯著抗腫瘤效果。

2. **文獻名稱**:"ImmunoPET imaging of glypican-3 in hepatocellular carcinoma with 89Zr-labeled antibodies"

**作者**:Fernandez A, et al.

**摘要**:研究利用鋯-89標(biāo)記的GPC3抗體進行免疫PET成像,證明其在肝細胞癌小鼠模型中可高靈敏度檢測腫瘤,為臨床無創(chuàng)診斷提供了潛在工具。

3. **文獻名稱**:"Chimeric antigen receptor T cells targeting glypican-3 suppress hepatocellular carcinoma growth"

**作者**:Gao H, et al.

**摘要**:開發(fā)了靶向GPC3的CAR-T細胞療法,體外和體內(nèi)實驗顯示其能特異性識別并殺傷GPC3陽性肝癌細胞,且在小鼠模型中顯著抑制腫瘤進展。

4. **文獻名稱**:"GPC3 antibody-drug conjugate exhibits potent antitumor activity against hepatocellular carcinoma"

**作者**:Li W, et al.

**摘要**:構(gòu)建了GPC3抗體-藥物偶聯(lián)物(ADC),通過靶向遞送細胞毒性藥物,在多種肝癌模型中有效誘導(dǎo)腫瘤細胞凋亡,并與索拉非尼聯(lián)用增強療效。

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建議通過PubMed或Web of Science檢索具體文獻以獲取完整信息。

       

背景信息

The glypican-3 (GPC3) antibody targets GPC3. a cell surface heparan sulfate proteoglycan anchored to the plasma membrane. GPC3 is part of the glypican family, which regulates cellular signaling pathways (e.g., Wnt, Hedgehog, YAP) during embryonic development. While minimally expressed in healthy adult tissues, GPC3 is overexpressed in several cancers, particularly hepatocellular carcinoma (HCC), malignant melanoma, and ovarian cancer, making it a promising tumor biomarker and therapeutic target.

GPC3 antibodies have emerged as critical tools in cancer diagnostics and therapy. In diagnostics, they enable immunohistochemical detection of GPC3 in tumor biopsies or liquid biopsies, aiding HCC differentiation from benign liver conditions. Therapeutically, GPC3 antibodies are engineered into antibody-drug conjugates (ADCs), bispecific antibodies, or CAR-T cell therapies. For instance, codrituzumab (an anti-GPC3 monoclonal antibody) and YP7 (an ADC) have shown preclinical efficacy by delivering cytotoxic agents directly to GPC3-positive tumors. CAR-T cells targeting GPC3 have demonstrated antitumor activity in early-phase clinical trials for HCC.

Challenges include tumor heterogeneity in GPC3 expression and potential off-target effects. Ongoing research focuses on optimizing antibody affinity, developing combination therapies (e.g., with immune checkpoint inhibitors), and exploring novel formats like nanobodies to enhance tumor penetration. Overall, GPC3 antibodies represent a versatile platform for precision oncology, with continued advancements expected to improve cancer detection and treatment outcomes.

       
關(guān)鍵字: GPC3抗體;GPC3;GPC3 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (3年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:3年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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