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CAMK4抗體,Mouse Monoclonal CAMK4 Antibody
  • CAMK4抗體,Mouse Monoclonal CAMK4 Antibody
  • CAMK4抗體,Mouse Monoclonal CAMK4 Antibody
  • CAMK4抗體,Mouse Monoclonal CAMK4 Antibody

CAMK4抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:CAMK4抗體英文名稱:Mouse Monoclonal CAMK4 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 571 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點: CAMK4
2025-05-10 CAMK4抗體 Mouse Monoclonal CAMK4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 571 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesIV; caMK; CaMK IV; CaMK-GR
Entrez GeneID814
clone8C5B8
WB Predicted band size58kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CAMK4 (AA: 35-292 ) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using CAMK4 mouse mAb against Jurkat (1), SK-N-SH (2), Raji (3), and HeLa (4) cell lysate.    


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       Immunofluorescence analysis of HepG2 cells using CAMK4 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using CAMK4 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using CAMK4 mouse mAb with DAB staining.    


           

參考文獻

以下是關(guān)于CAMK4抗體的3篇參考文獻示例(注:以下內(nèi)容為模擬,非真實文獻,僅供格式參考):

1. **標題**:*CAMK4 expression in autoimmune diseases: Role of antibody-based detection*

**作者**:Smith A, et al.

**摘要**:研究利用CAMK4抗體分析其在類風濕性關(guān)節(jié)炎患者外周血單核細胞中的表達,發(fā)現(xiàn)CAMK4水平升高與炎癥因子IL-17的異常激活相關(guān)。

2. **標題**:*CAMK4 regulates T cell differentiation via NFAT signaling: Insights from antibody blockade experiments*

**作者**:Chen L, et al.

**摘要**:通過CAMK4抗體阻斷實驗,揭示其在T細胞分化中通過調(diào)控NFAT入核影響Th17細胞功能,提示其作為潛在免疫治療靶點。

3. **標題**:*Development of a high-specificity monoclonal CAMK4 antibody for neurodegenerative disease models*

**作者**:Wang Y, et al.

**摘要**:報道一種新型單克隆CAMK4抗體的開發(fā)與驗證,應用于阿爾茨海默病模型小鼠腦組織檢測,發(fā)現(xiàn)CAMK4與tau蛋白磷酸化存在關(guān)聯(lián)。

(如需真實文獻,建議通過PubMed或Google Scholar檢索關(guān)鍵詞“CAMK4 antibody”或“CAMK4 function”。)

       

背景信息

The CAMK4 antibody is a crucial tool for studying calcium/calmodulin-dependent protein kinase IV (CAMK4), a serine/threonine kinase involved in calcium-mediated signaling pathways. CAMK4 is expressed in various tissues, including the brain, immune cells, and testes, and plays roles in gene transcription regulation, synaptic plasticity, and immune response modulation. It is activated by calcium/calmodulin binding and phosphorylates downstream targets like CREB (cAMP response element-binding protein), influencing cellular processes such as neuronal differentiation and T-cell activation.

CAMK4 antibodies are widely used in research to detect protein expression, localization, and activity in both normal and pathological conditions. They are essential in studying CAMK4's involvement in diseases like autoimmune disorders, neurodegenerative diseases, and cancer. Common applications include Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Many CAMK4 antibodies are polyclonal or monoclonal, with specificity validated via knockout controls or peptide blocking assays.

Researchers must consider cross-reactivity with related kinases (e.g., CAMK2) and optimize experimental conditions (e.g., fixation methods, buffer compositions) to ensure accuracy. Commercial CAMK4 antibodies often include datasheets detailing epitope regions, host species (e.g., rabbit, mouse), and recommended dilutions. Understanding CAMK4's structural domains (kinase, regulatory, and nuclear localization sequences) aids in selecting antibodies targeting functional regions. Overall, CAMK4 antibodies remain pivotal in elucidating calcium signaling mechanisms and their therapeutic implications.

       
關(guān)鍵字: CAMK4抗體;CAMK4;CAMK4 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (3年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:3年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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