| 中文名稱:FUT4抗體 | 英文名稱:Mouse Monoclonal FUT4 Antibody |
| 品牌: 艾普蒂 | 產(chǎn)地: 武漢 |
| 保存條件: Stored at -20°C for 607 year. Avoid repeated freeze / thaw cycles. | 產(chǎn)品類別: 抗體 |
| 重組: 否 | 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA |
| 種屬反應(yīng)性: Human,Mouse,Rat | 宿主: Mouse |
| 偶聯(lián)物: 無(wú) | 靶點(diǎn): FUT4 |
| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨詢技術(shù) | Human,Mouse,Rat |
| IHC | 咨詢技術(shù) | Human,Mouse,Rat |
| ICC | 技術(shù)咨詢 | Human,Mouse,Rat |
| FCM | 咨詢技術(shù) | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | LeX; CD15; ELFT; FCT3A; FUTIV; SSEA-1; FUC-TIV |
| Entrez GeneID | 2526 |
| clone | 6B11B4 |
| WB Predicted band size | 59kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human FUT4 (AA: 199-302) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Western blot analysis using FUT4 mouse mAb against Jurkat cell lysate.
以下是3篇關(guān)于FUT4抗體的虛構(gòu)參考文獻(xiàn)示例(僅供格式參考,實(shí)際文獻(xiàn)需自行檢索):
1. **文獻(xiàn)名稱**:FUT4 promotes breast cancer metastasis via enhancing EGFR stability
**作者**:Zhang Y, et al. (2021)
**摘要**:本研究通過(guò)免疫組化分析發(fā)現(xiàn)FUT4在乳腺癌組織中高表達(dá),其通過(guò)糖基化修飾穩(wěn)定EGFR蛋白,促進(jìn)腫瘤細(xì)胞侵襲和肺轉(zhuǎn)移,靶向FUT4抗體可抑制該過(guò)程。
2. **文獻(xiàn)名稱**:FUT4 regulates stemness in colorectal cancer via CD44 glycosylation
**作者**:Li F, et al. (2019)
**摘要**:證實(shí)FUT4抗體可阻斷結(jié)腸癌干細(xì)胞表面CD44分子的巖藻糖基化修飾,抑制腫瘤球形成能力和化療耐藥性,提示FUT4是靶向癌癥干細(xì)胞的潛在標(biāo)志物。
3. **文獻(xiàn)名稱**:FUT4-specific antibody inhibits leukocyte adhesion in inflammation
**作者**:Wang L, et al. (2020)
**摘要**:開發(fā)高特異性FUT4單克隆抗體,證明其能有效抑制中性粒細(xì)胞表面Sialyl Lewis X合成,減少炎癥模型中白細(xì)胞與內(nèi)皮細(xì)胞的黏附,為抗炎治療提供新策略。
(注:以上為模擬內(nèi)容,實(shí)際文獻(xiàn)請(qǐng)通過(guò)PubMed/Google Scholar檢索關(guān)鍵詞"FUT4 antibody"或"FUT8 knockout"等)
FUT4 antibody targets the human α-1.3-fucosyltransferase 4 (FUT4), also known as ELAM-1 ligand fucosyltransferase (ELC-1), a key enzyme in glycoconjugate biosynthesis. FUT4 catalyzes the transfer of fucose to terminal glycan structures, forming Lewis-type antigens like Lewis X (LeX) and sialyl-Lewis X (sLeX). These glycans play critical roles in cell-cell recognition, immune responses, and inflammatory processes. Notably, sLeX serves as a ligand for selectins, mediating leukocyte homing and cancer cell adhesion during metastasis. FUT4 is highly expressed in certain epithelial cancers, stem cells, and hematopoietic cells, correlating with tumor progression, drug resistance, and poor prognosis.
FUT4 antibodies are widely used in research to investigate glycosylation patterns in cancer biology, inflammation, and developmental processes. They enable detection of FUT4 expression via techniques like immunohistochemistry, flow cytometry, and Western blotting. Such studies help clarify FUT4's regulatory mechanisms in pathological conditions and its potential as a therapeutic target. Commercially available FUT4 antibodies are typically monoclonal or polyclonal, validated for specificity against recombinant or native FUT4 protein. Their applications extend to biomarker discovery and evaluating glycosylation-targeted therapies in preclinical models.
| 成立日期 | 2024-06-24 (3年) | 注冊(cè)資本 | 50萬(wàn)(元) |
| 員工人數(shù) | 1-10人 | 年?duì)I業(yè)額 | ¥ 100萬(wàn)以內(nèi) |
| 主營(yíng)行業(yè) | 中間體,化學(xué)試劑 | 經(jīng)營(yíng)模式 | 貿(mào)易,工廠,試劑,定制,服務(wù) |
| 產(chǎn)品名稱 | 價(jià)格 | 公司名稱 | 報(bào)價(jià)日期 | |
|---|---|---|---|---|
| ¥1098 |
VIP4年
|
上海滬震實(shí)業(yè)有限公司
|
2026-07-24 | |
| 詢價(jià) |
VIP4年
|
武漢佰樂博生物技術(shù)有限公司
|
2026-07-24 | |
| ¥2520 |
VIP7年
|
上海澤葉生物科技有限公司
|
2026-07-24 |