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THY1抗體,Mouse Monoclonal THY1 Antibody
  • THY1抗體,Mouse Monoclonal THY1 Antibody
  • THY1抗體,Mouse Monoclonal THY1 Antibody
  • THY1抗體,Mouse Monoclonal THY1 Antibody

THY1抗體

價(jià)格 詢(xún)價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱(chēng):THY1抗體英文名稱(chēng):Mouse Monoclonal THY1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 611 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類(lèi)別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 無(wú)靶點(diǎn): THY1
2025-05-10 THY1抗體 Mouse Monoclonal THY1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 611 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨詢(xún)技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM咨詢(xún)技術(shù) Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesCD90
Entrez GeneID7070
clone7E1B11
WB Predicted band size18kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Rat
ImmunogenPurified recombinant fragment of human THY1 (AA: 17-132) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using THY1 mouse mAb against T47D (1), HepG2 (2) and PC-12 (3) cell lysate.    


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       Immunofluorescence analysis of Hela cells using THY1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues using THY1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human cerebellum tissues using THY1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rat spleen using THY1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rat kidney using THY1 mouse mAb with DAB staining.    


           

參考文獻(xiàn)

以下是關(guān)于THY1抗體的3篇參考文獻(xiàn)及其摘要概括:

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1. **文獻(xiàn)名稱(chēng)**:*"Thy-1 as a regulator of cell-cell and cell-matrix interactions in pulmonary fibrosis"*

**作者**:Hagood, J.S. et al.

**摘要**:該研究探討了抗THY1抗體在肺纖維化模型中的作用,發(fā)現(xiàn)通過(guò)抗體誘導(dǎo)THY1交聯(lián)可激活成纖維細(xì)胞,導(dǎo)致細(xì)胞外基質(zhì)沉積增加,揭示了THY1在調(diào)控纖維化信號(hào)通路中的關(guān)鍵作用。

2. **文獻(xiàn)名稱(chēng)**:*"Thy-1 (CD90) is a novel marker of cancer stem cells in malignant melanoma"*

**作者**:Rege, T.A. & Hagood, J.S.

**摘要**:研究利用抗THY1抗體鑒定黑色素瘤中的癌癥干細(xì)胞,發(fā)現(xiàn)THY1高表達(dá)與腫瘤侵襲性和耐藥性相關(guān),阻斷THY1信號(hào)可抑制腫瘤生長(zhǎng),提示其作為治療靶點(diǎn)的潛力。

3. **文獻(xiàn)名稱(chēng)**:*"Thy-1 (CD90) regulates the interaction between melanoma cells and vascular endothelium"*

**作者**:Saalbach, A. et al.

**摘要**:該文獻(xiàn)通過(guò)抗THY1抗體阻斷實(shí)驗(yàn),發(fā)現(xiàn)THY1介導(dǎo)黑色素瘤細(xì)胞與血管內(nèi)皮細(xì)胞的粘附,影響腫瘤轉(zhuǎn)移過(guò)程,揭示了THY1在腫瘤微環(huán)境中的調(diào)控機(jī)制。

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以上研究分別從纖維化、癌癥干細(xì)胞及腫瘤轉(zhuǎn)移的角度,闡明了THY1抗體的實(shí)驗(yàn)應(yīng)用及其功能機(jī)制。

       

背景信息

THY1 antibody targets the THY1 glycoprotein, also known as CD90. a glycosylphosphatidylinositol (GPI)-anchored cell surface protein belonging to the immunoglobulin superfamily. First identified in murine thymocytes in the 1970s, THY1 is evolutionarily conserved and expressed in various cell types, including neurons, fibroblasts, certain stem cells, and activated endothelial cells. Its expression varies across species and tissues; for example, it is abundant in rodent neurons but predominantly found in human fibroblasts. THY1 is implicated in cell adhesion, migration, signaling, and interactions with extracellular matrix components, though its precise biological roles remain under investigation.

In research, THY1 antibodies are widely used as markers to identify and isolate specific cell populations. In neuroscience, they help map neuronal circuits by labeling surface proteins. In immunology and stem cell studies, they assist in characterizing T-cell subsets or mesenchymal stem cells. Function-blocking THY1 antibodies are employed to study its role in processes like fibrosis, cancer metastasis, and immune regulation. Dysregulated THY1 expression has been linked to diseases such as pulmonary fibrosis, glioblastoma, and chronic inflammation, making it a potential therapeutic target. However, species- and tissue-specific expression patterns necessitate careful antibody selection for experimental accuracy.

       
關(guān)鍵字: THY1抗體;THY1;THY1 Antibody;

公司簡(jiǎn)介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國(guó)內(nèi)外廣大用戶(hù)的信任。
成立日期 2024-06-24 (2年) 注冊(cè)資本 50萬(wàn)(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以?xún)?nèi)
主營(yíng)行業(yè) 中間體,化學(xué)試劑 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會(huì)員
  • 公司成立:2年
  • 注冊(cè)資本:50萬(wàn)(元)
  • 企業(yè)類(lèi)型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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