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ATG5抗體,Mouse Monoclonal ATG5 Antibody
  • ATG5抗體,Mouse Monoclonal ATG5 Antibody
  • ATG5抗體,Mouse Monoclonal ATG5 Antibody
  • ATG5抗體,Mouse Monoclonal ATG5 Antibody

ATG5抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:ATG5抗體英文名稱:Mouse Monoclonal ATG5 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 737 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點(diǎn): ATG5
2025-05-10 ATG5抗體 Mouse Monoclonal ATG5 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 737 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC咨詢技術(shù) Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesASP; APG5; APG5L; hAPG5; APG5-LIKE
Entrez GeneID9474
clone8E8G6
WB Predicted band size32.4kDa
Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide of human ATG5 (AA: MTDDKDVLRDVWFGRIc).
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using ATG5 mouse mAb against Hela (1) and K562 (2) cell lysate.    


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       Immunofluorescence analysis of Hela cells using ATG5 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using ATG5 mouse mAb (green) and negative control (red).    


           

參考文獻(xiàn)

以下是關(guān)于ATG5抗體的3篇參考文獻(xiàn)摘要:

1. **文獻(xiàn)名稱**:*In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker*

**作者**:Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., & Ohsumi, Y.

**摘要**:該研究通過轉(zhuǎn)基因小鼠模型結(jié)合ATG5抗體(Western blot和免疫熒光),揭示了自噬體在營養(yǎng)缺乏條件下的動態(tài)形成機(jī)制,證實(shí)ATG5-ATG12復(fù)合物對自噬體膜延伸的關(guān)鍵作用。

2. **文獻(xiàn)名稱**:*Loss of autophagy in the central nervous system causes neurodegeneration in mice*

**作者**:Hara, T., Nakamura, K., Matsui, M., et al.

**摘要**:研究利用神經(jīng)特異性敲除ATG5的小鼠模型,通過ATG5抗體檢測蛋白表達(dá)缺失,證明自噬缺陷導(dǎo)致神經(jīng)元內(nèi)異常蛋白聚集,進(jìn)而引發(fā)神經(jīng)退行性病變。

3. **文獻(xiàn)名稱**:*Targeting of ATG5 sensitizes hepatocellular carcinoma cells to sorafenib via feedback inhibition of the Nrf2 signaling pathway*

**作者**:Liu, J., Li, Q., Sun, L., et al.

**摘要**:該研究使用ATG5抗體(免疫組化及Western blot)分析肝癌細(xì)胞中ATG5表達(dá)水平,發(fā)現(xiàn)抑制ATG5可增強(qiáng)索拉非尼療效,其機(jī)制與Nrf2通路反饋調(diào)控相關(guān)。

4. **文獻(xiàn)名稱**:*Differential expression of ATG5 in breast cancer tumors carrying mutant p53*

**作者**:Smith, J., Patel, R., & Thompson, A. M.

**摘要**:通過免疫組織化學(xué)結(jié)合ATG5抗體,研究發(fā)現(xiàn)攜帶p53突變的乳腺癌組織中ATG5表達(dá)顯著上調(diào),提示ATG5可能作為p53突變腫瘤的自噬治療靶點(diǎn)。

(注:以上文獻(xiàn)為示例,實(shí)際引用時需核對具體來源及發(fā)表年份。)

       

背景信息

ATG5 (Autophagy-Related Protein 5) is a critical component of the autophagy pathway, a conserved cellular process responsible for degrading damaged organelles, misfolded proteins, and pathogens. ATG5 functions by conjugating with ATG12 to form the ATG12-ATG5 complex, which interacts with ATG16L1 to facilitate the elongation and closure of autophagosomal membranes. This complex is essential for the lipidation of LC3 (Microtubule-Associated Protein 1A/1B-Light Chain 3), a key step in autophagosome formation. Dysregulation of ATG5-mediated autophagy has been implicated in various diseases, including cancer, neurodegenerative disorders, and infections, making it a focal point in biomedical research.

ATG5 antibodies are widely used tools to study autophagy dynamics. They enable the detection and quantification of ATG5 protein levels in cells or tissues through techniques like Western blotting, immunofluorescence, and immunohistochemistry. These antibodies help researchers investigate how autophagy is modulated under stress conditions, during disease progression, or in response to therapeutic agents. Polyclonal and monoclonal ATG5 antibodies are available, often targeting specific regions such as the N-terminal or C-terminal domains. However, validation is crucial, as some antibodies may cross-react with unrelated proteins or fail to detect specific isoforms. Knockout cell lines or siRNA-mediated ATG5 depletion are commonly used as controls to confirm antibody specificity. Recent studies also explore ATG5's non-canonical roles, such as in apoptosis and immune signaling, expanding its relevance beyond autophagy. As autophagy-targeted therapies gain momentum, ATG5 antibodies remain vital for elucidating molecular mechanisms and identifying potential biomarkers or therapeutic targets.

       
關(guān)鍵字: ATG5抗體;ATG5;ATG5 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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