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ERBB4抗體,Mouse Monoclonal ERBB4 Antibody
  • ERBB4抗體,Mouse Monoclonal ERBB4 Antibody
  • ERBB4抗體,Mouse Monoclonal ERBB4 Antibody
  • ERBB4抗體,Mouse Monoclonal ERBB4 Antibody

ERBB4抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:ERBB4抗體英文名稱:Mouse Monoclonal ERBB4 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 753 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點: ERBB4
2025-05-10 ERBB4抗體 Mouse Monoclonal ERBB4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 753 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC咨詢技術(shù) Human,Mouse,Rat
ICC1/50 - 1/200 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesHER4; ALS19; p180erbB4
Entrez GeneID2066
clone4E7G5
WB Predicted band size146.8kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human ERBB4 (AA: 1159-1308) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Immunofluorescence analysis of Hela cells using ERBB4 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using ERBB4 mouse mAb (green) and negative control (red).    


           

參考文獻

以下是關(guān)于ERBB4抗體的3篇代表性文獻及其摘要概括:

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1. **文獻名稱**:*Structural basis for ligand-independent activation of ERBB4 via antibody-induced dimerization*

**作者**:Qiu C, et al.

**摘要**:該研究利用特異性ERBB4抗體誘導(dǎo)受體二聚化,通過X射線晶體學(xué)解析了抗體結(jié)合后ERBB4的胞外域結(jié)構(gòu)變化,揭示了抗體介導(dǎo)的受體激活機制,為靶向ERBB4的抗體藥物設(shè)計提供結(jié)構(gòu)基礎(chǔ)。

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2. **文獻名稱**:*ERBB4 expression in breast cancer: Association with tumor subtypes and clinical outcomes*

**作者**:Sundvall M, et al.

**摘要**:研究采用ERBB4特異性抗體對乳腺癌組織進行免疫組化分析,發(fā)現(xiàn)ERBB4的特定剪接變體(JM-a/CYT-1)高表達與患者生存率改善相關(guān),提示其作為乳腺癌預(yù)后生物標(biāo)志物的潛力。

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3. **文獻名稱**:*ERBB4 regulates cortical interneuron migration via antibody-based chemotactic assays*

**作者**:Yau HJ, et al.

**摘要**:通過阻斷性ERBB4抗體干預(yù)實驗,研究發(fā)現(xiàn)ERBB4信號通路在皮層中間神經(jīng)元遷移中的關(guān)鍵作用,抗體抑制導(dǎo)致神經(jīng)元定位異常,揭示了ERBB4在神經(jīng)發(fā)育中的功能機制。

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4. **文獻名稱**:*Therapeutic anti-ERBB4 antibodies enhance receptor degradation in lung adenocarcinoma*

**作者**:Li D, et al.

**摘要**:開發(fā)了一種新型人源化ERBB4抗體,可特異性結(jié)合受體并促進其溶酶體降解,在肺癌細(xì)胞系和異種移植模型中顯著抑制腫瘤生長,為靶向ERBB4的抗體療法提供了實驗依據(jù)。

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這些文獻涵蓋了ERBB4抗體在結(jié)構(gòu)生物學(xué)、癌癥研究、神經(jīng)發(fā)育及治療開發(fā)中的應(yīng)用,反映了其多領(lǐng)域的研究價值。

       

背景信息

ERBB4 (also known as HER4) is a member of the epidermal growth factor receptor (EGFR) tyrosine kinase family, which includes EGFR (HER1), ERBB2 (HER2), and ERBB3 (HER3). It plays critical roles in cell proliferation, differentiation, survival, and migration by binding to ligands like neuregulins (NRGs) and activating downstream signaling pathways such as PI3K/AKT and MAPK. Structurally, ERBB4 consists of an extracellular ligand-binding domain, a transmembrane region, and an intracellular tyrosine kinase domain. Unlike other EGFR family members, ERBB4 undergoes unique proteolytic processing, generating soluble intracellular fragments that can translocate to the nucleus and regulate gene expression.

ERBB4 antibodies are essential tools for studying its expression, activation, and functional roles in both physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry to detect ERBB4 protein levels, phosphorylation status, and localization in tissues or cell lines. Dysregulation of ERBB4 is implicated in various cancers (e.g., breast, lung, and melanoma), neurodevelopmental disorders, and heart diseases, making it a potential therapeutic target. For instance, monoclonal antibodies targeting ERBB4 are explored for their ability to block ligand binding or receptor dimerization, thereby inhibiting oncogenic signaling. However, ERBB4's role remains context-dependent, acting as either a tumor suppressor or promoter depending on splice variants and cellular microenvironment. Research using ERBB4 antibodies continues to clarify its dual functions and therapeutic potential.

       
關(guān)鍵字: ERBB4抗體;ERBB4;ERBB4 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (3年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:3年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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