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SK2抗體,Mouse Monoclonal SK2 Antibody
  • SK2抗體,Mouse Monoclonal SK2 Antibody
  • SK2抗體,Mouse Monoclonal SK2 Antibody
  • SK2抗體,Mouse Monoclonal SK2 Antibody

SK2抗體 新品

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:SK2抗體英文名稱:Mouse Monoclonal SK2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 798 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點: SK2
2025-05-10 SK2抗體 Mouse Monoclonal SK2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 798 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesSPHK2; SK-2; SPK 2; SPK-2
Entrez GeneID56848
clone3C8D3
WB Predicted band size69.2kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide of human SK2 (AA: 36-52).
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Immunofluorescence analysis of HeLa cells using SK2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of HeLa cells using SK2 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using SK2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues using SK2 mouse mAb with DAB staining.    


           

參考文獻

以下是關(guān)于SK2抗體的3篇參考文獻及其摘要概括:

1. **文獻名稱**: "Small-conductance calcium-activated potassium channels: insights into their roles in cardiovascular disease"

**作者**: Bond, C.T., et al.

**摘要**: 該研究利用特異性SK2抗體,在小鼠心臟和腦組織中定位SK2通道蛋白,發(fā)現(xiàn)其在調(diào)節(jié)神經(jīng)元興奮性和心臟節(jié)律中起關(guān)鍵作用,抗體應(yīng)用證實了SK2在心肌細胞中的高表達。

2. **文獻名稱**: "SK2 channel regulation of neuronal excitability and behavior in learning and memory"

**作者**: Allen, D., et al.

**摘要**: 通過SK2抗體進行免疫組化和Western blot分析,研究發(fā)現(xiàn)海馬區(qū)SK2通道通過調(diào)控突觸后電流影響突觸可塑性,抗體實驗顯示SK2缺失導(dǎo)致小鼠空間記憶能力下降。

3. **文獻名稱**: "Pharmacological modulation of SK2 channels alters dendritic excitability and synaptic plasticity"

**作者**: Lin, M.T., et al.

**摘要**: 該文獻使用SK2抗體阻斷實驗,證明SK2通道在樹突信號整合中的作用,抗體介導(dǎo)的功能抑制揭示了其對長時程增強(LTP)的調(diào)節(jié)機制。

以上研究均通過SK2抗體實現(xiàn)了蛋白定位、功能驗證或病理機制探索。

       

背景信息

**Background of SK2 Antibody**

The SK2 antibody targets the small conductance calcium-activated potassium channel protein 2 (SK2. KCa2.2), encoded by the *KCNN2* gene. SK2 channels are voltage-independent potassium channels activated by intracellular calcium, playing critical roles in regulating neuronal excitability, synaptic plasticity, and cardiac rhythmicity. They are predominantly expressed in the brain, particularly in regions like the hippocampus, cortex, and cerebellum, where they modulate afterhyperpolarization currents (IAHP) to influence firing patterns and synaptic transmission. Dysregulation of SK2 channels is implicated in neurological disorders, including epilepsy, ataxia, and cognitive deficits, as well as cardiac arrhythmias.

SK2 antibodies are widely used in neuroscience and cardiovascular research to study channel expression, localization, and function. They enable detection via techniques like Western blot, immunohistochemistry, and immunofluorescence. Studies utilizing SK2 antibodies have revealed its interaction with calmodulin for calcium sensing and its role in diseases, such as spinocerebellar ataxia and atrial fibrillation. Additionally, SK2 channels are explored as therapeutic targets, with modulators under investigation for treating cognitive impairment or arrhythmias. The development of specific SK2 antibodies has been pivotal in advancing understanding of its physiological and pathological mechanisms.

       
關(guān)鍵字: SK2抗體;SK2;SK2 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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