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FOXP3抗體,Mouse Monoclonal FOXP3 Antibody
  • FOXP3抗體,Mouse Monoclonal FOXP3 Antibody
  • FOXP3抗體,Mouse Monoclonal FOXP3 Antibody
  • FOXP3抗體,Mouse Monoclonal FOXP3 Antibody

FOXP3抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:FOXP3抗體英文名稱:Mouse Monoclonal FOXP3 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 806 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點: FOXP3
2025-05-10 FOXP3抗體 Mouse Monoclonal FOXP3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 806 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rabbit
IF咨詢技術(shù) Human,Mouse,Rabbit
IHC1/100 - 1/500 Human,Mouse,Rabbit
ICC技術(shù)咨詢 Human,Mouse,Rabbit
FCM1/200 - 1/400 Human,Mouse,Rabbit
Elisa1/10000 Human,Mouse,Rabbit
   

產(chǎn)品詳情

AliasesJM2; AIID; IPEX; PIDX; XPID; DIETER
Entrez GeneID50943
clone4F12A2
WB Predicted band size47.3kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rabbit
ImmunogenPurified recombinant fragment of human FOXP3 (AA: 297-431) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using FOXP3 mouse mAb against C2C12(1) Hela(2)Jurkat(3) cell lysate.    


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       Flow cytometric analysis of HeLa cells using FOXP3 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using FOXP3 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using FOXP3 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using FOXP3 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rabbit spinal cord using FOXP3 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rabbit cerebellum using FOXP3 mouse mAb with DAB staining.    


           

參考文獻(xiàn)

以下是關(guān)于FOXP3抗體的3篇代表性文獻(xiàn),按發(fā)表時間排序:

1. **文獻(xiàn)名稱**:*Control of regulatory T cell development by the transcription factor Foxp3*

**作者**:Hori, S., Nomura, T., & Sakaguchi, S.

**摘要**:該研究首次克隆了小鼠Foxp3基因,證明其在調(diào)節(jié)性T細(xì)胞(Treg)中的特異性表達(dá),并發(fā)現(xiàn)Foxp3缺失會導(dǎo)致小鼠自身免疫疾病,為后續(xù)FOXP3抗體的開發(fā)提供了理論基礎(chǔ)。

2. **文獻(xiàn)名稱**:*Foxp3 programs the development and function of CD4+CD25+ regulatory T cells*

**作者**:Fontenot, J.D., Gavin, M.A., & Rudensky, A.Y.

**摘要**:通過基因工程和抗體標(biāo)記技術(shù),揭示了Foxp3對Treg細(xì)胞發(fā)育和功能的關(guān)鍵調(diào)控作用,并驗證了FOXP3抗體在流式細(xì)胞術(shù)和免疫組化中的應(yīng)用價值。

3. **文獻(xiàn)名稱**:*Specificity of FOXP3 antibodies in human tissues and cells: Critical assessment for accurate Treg identification*

**作者**:Allan, S.E., et al.

**摘要**:系統(tǒng)評估了多種市售FOXP3抗體在人類樣本中的特異性,指出部分抗體存在交叉反應(yīng)性,強(qiáng)調(diào)了選擇可靠抗體對Treg細(xì)胞精準(zhǔn)檢測的重要性。

這些文獻(xiàn)涵蓋了FOXP3的功能機(jī)制、抗體開發(fā)及實際應(yīng)用中的關(guān)鍵技術(shù)挑戰(zhàn),是相關(guān)領(lǐng)域的基礎(chǔ)參考資料。

       

背景信息

The FOXP3 antibody is a crucial tool in immunology research, targeting the FOXP3 (Forkhead Box P3) protein, a transcription factor primarily expressed in regulatory T cells (Tregs). Discovered in the early 2000s, FOXP3 is a master regulator of Treg development and function, essential for maintaining immune tolerance and preventing autoimmune diseases. Mutations in the FOXP3 gene cause IPEX syndrome (Immune dysregulation, Polyendocrinopathy, Enteropathy, X-linked), highlighting its biological significance.

FOXP3 antibodies enable the identification and study of Tregs in both human and murine models. They are widely used in techniques like flow cytometry, immunohistochemistry, and Western blotting to detect FOXP3 expression, quantify Treg populations, or assess their functional status in tissues. These antibodies have advanced research in cancer immunology, autoimmune disorders (e.g., rheumatoid arthritis, type 1 diabetes), and transplantation, where Treg dysregulation plays a key role.

Commercial FOXP3 antibodies vary in specificity, targeting different epitopes (e.g., N-terminal or C-terminal regions) and showing species cross-reactivity differences. Validation is critical, as FOXP3 expression can be transient or heterogeneous in activated T cells. Additionally, FOXP3 antibodies have diagnostic potential, with clinical studies exploring Treg levels as biomarkers for disease progression or therapeutic responses. Their utility continues to grow with the development of Treg-targeted therapies and precision immunology approaches.

       
關(guān)鍵字: FOXP3抗體;FOXP3;FOXP3 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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