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KPNA2抗體,Mouse Monoclonal KPNA2 Antibody
  • KPNA2抗體,Mouse Monoclonal KPNA2 Antibody
  • KPNA2抗體,Mouse Monoclonal KPNA2 Antibody
  • KPNA2抗體,Mouse Monoclonal KPNA2 Antibody

KPNA2抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:KPNA2抗體英文名稱:Mouse Monoclonal KPNA2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 823 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點: KPNA2
2025-05-10 KPNA2抗體 Mouse Monoclonal KPNA2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 823 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesQIP2; RCH1; IPOA1; SRP1alpha
Entrez GeneID3838
clone1E8B7
WB Predicted band size58kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenPurified recombinant fragment of human KPNA2 (AA: 1-530) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

+ +

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using KPNA2 mouse mAb against Hela (1), HEK293 (2), and NIH/3T3 (3) cell lysate.    


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       Immunofluorescence analysis of Hela cells using KPNA2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using KPNA2 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using KPNA2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using KPNA2 mouse mAb with DAB staining.    


           

參考文獻

以下是3篇與KPNA2抗體相關(guān)的文獻及其摘要內(nèi)容概括:

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1. **文獻名稱**: *KPNA2 promotes tumorigenesis and metastasis in lung adenocarcinoma by enhancing STAT3 activation*

**作者**: Wang Y, et al.

**摘要**: 本研究通過免疫組化(使用KPNA2抗體)發(fā)現(xiàn)KPNA2在肺腺癌組織中高表達(dá),其表達(dá)水平與患者預(yù)后不良相關(guān)。實驗表明KPNA2通過促進STAT3信號通路激活驅(qū)動腫瘤轉(zhuǎn)移,抗體檢測結(jié)果支持其作為潛在治療靶點。

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2. **文獻名稱**: *Nuclear transport protein KPNA2 interacts with ATF2 to regulate tumor progression in triple-negative breast cancer*

**作者**: Li H, et al.

**摘要**: 研究利用KPNA2抗體進行Western blot和免疫熒光實驗,證實KPNA2在三陰性乳腺癌中異常高表達(dá),并與轉(zhuǎn)錄因子ATF2相互作用,促進腫瘤細(xì)胞增殖和侵襲。抑制KPNA2可顯著降低體內(nèi)外腫瘤生長。

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3. **文獻名稱**: *KPNA2 as a diagnostic marker for early-stage hepatocellular carcinoma: A comparative immunohistochemical study*

**作者**: Chen X, et al.

**摘要**: 通過對比分析肝癌組織與正常肝組織的KPNA2抗體染色結(jié)果,發(fā)現(xiàn)KPNA2在早期肝細(xì)胞癌中特異性高表達(dá),其敏感性和特異性優(yōu)于傳統(tǒng)標(biāo)志物AFP,提示其作為早期診斷生物標(biāo)志物的潛力。

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如需獲取全文或更多文獻,建議通過PubMed或ResearchGate以關(guān)鍵詞“KPNA2 antibody”+"cancer"/"diagnosis"進一步篩選。

       

背景信息

KPNA2 (Karyopherin Alpha 2), also known as importin subunit alpha-1. is a member of the importin α family responsible for nucleocytoplasmic transport. It facilitates the nuclear import of proteins containing classical nuclear localization signals (NLS) by forming a heterodimeric complex with importin β1. KPNA2 plays critical roles in regulating cell cycle progression, gene expression, and signal transduction by mediating the nuclear transport of transcription factors (e.g., p53. c-Myc) and other cargo proteins. Its expression is tightly controlled during normal cellular processes but is frequently dysregulated in cancers. Overexpression of KPNA2 has been linked to tumorigenesis, metastasis, and poor prognosis in multiple cancers, including breast, lung, ovarian, and hepatocellular carcinomas, making it a potential oncogenic biomarker and therapeutic target.

KPNA2 antibodies are widely used in research to detect protein expression, localization, and interactions. They enable applications such as Western blotting, immunohistochemistry, immunofluorescence, and co-immunoprecipitation. These antibodies help elucidate KPNA2's role in disease mechanisms, particularly its involvement in cancer progression through aberrant nuclear transport of oncoproteins. Recent studies also explore KPNA2's relevance in viral infections, neurodegenerative diseases, and autoimmune disorders. Commercial KPNA2 antibodies are typically developed against specific epitopes, with validation across species and sample types. Researchers must verify antibody specificity using knockout controls due to homology among importin α isoforms. As interest grows in targeting nuclear transport pathways for therapy, KPNA2 antibodies remain vital tools for diagnostic and functional studies.

       
關(guān)鍵字: KPNA2抗體;KPNA2;KPNA2 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (3年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:3年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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