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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P00334(DKK2 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

DKK2 (Dickkopf-related protein 2) is a secreted glycoprotein belonging to the Dickkopf family, known for its regulatory role in the Wnt signaling pathway. Wnt signaling is critical for embryonic development, tissue homeostasis, and stem cell regulation, but its dysregulation is implicated in cancers, fibrosis, and bone diseases. DKK2 interacts with Wnt co-receptors LRP5/6 and Kremen proteins, acting as a context-dependent modulator—either inhibiting or enhancing Wnt/β-catenin signaling depending on cellular conditions. This dual role complicates its biological functions but highlights its therapeutic relevance.

DKK2 is overexpressed in certain cancers (e.g., liver, gastric, and colorectal cancers) where it may promote tumor progression, angiogenesis, or immune evasion. Conversely, in bone disorders like osteoporosis, reduced DKK2 activity correlates with impaired bone formation. Antibodies targeting DKK2 are thus valuable tools for both research and clinical applications. In research, they enable detection of DKK2 expression in tissues or biofluids, aiding mechanistic studies of Wnt-related pathologies. Therapeutically, anti-DKK2 antibodies are explored for neutralizing DKK2's oncogenic effects or modulating bone metabolism. Challenges remain in optimizing specificity due to structural similarities among DKK family members. Ongoing studies aim to clarify DKK2's context-dependent roles and validate its utility as a biomarker or therapeutic target.