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     The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P00465(ITGB3BP Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P00465(ITGB3BP Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

ITGB3BP (Integrin Beta 3 Binding Protein), also known as TAP20 or NRIF3. is a multifunctional protein involved in cell adhesion, signaling, and transcriptional regulation. It interacts with integrin β3 subunits, modulating integrin-mediated processes like cell migration, proliferation, and survival. Structurally, it contains an N-terminal nuclear localization signal, a central coiled-coil domain, and a C-terminal integrin-binding region, enabling its dual roles in both cytoplasmic/nuclear compartments.

ITGB3BP regulates transcriptional activity by interacting with nuclear receptors (e.g., thyroid hormone receptor) and transcription factors, influencing pathways such as NF-κB and MAPK. It also participates in DNA damage response and stress signaling. Dysregulation of ITGB3BP is linked to cancer progression, cardiovascular diseases, and immune disorders, highlighting its potential as a therapeutic target.

Antibodies targeting ITGB3BP are essential tools for studying its expression, localization, and function. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate its role in cellular processes and disease models. These antibodies are typically validated for specificity using knockout controls or siRNA knockdown. Commercial ITGB3BP antibodies are often raised against recombinant protein fragments or synthetic peptides corresponding to conserved regions. Researchers utilize them to explore ITGB3BP's involvement in tumor metastasis, angiogenesis, and drug resistance, providing insights into its clinical relevance.