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ARHGAP15抗體,Rabbit Polyclonal ARHGAP15 Antibody
  • ARHGAP15抗體,Rabbit Polyclonal ARHGAP15 Antibody
  • ARHGAP15抗體,Rabbit Polyclonal ARHGAP15 Antibody
  • ARHGAP15抗體,Rabbit Polyclonal ARHGAP15 Antibody

ARHGAP15抗體

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-11
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:ARHGAP15抗體英文名稱:Rabbit Polyclonal ARHGAP15 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 1812 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): ARHGAP15
2025-05-11 ARHGAP15抗體 Rabbit Polyclonal ARHGAP15 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 1812 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesBM046
WB Predicted band size55 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human ARHGAP15
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Jurkat cells, 293T cells, Primary antibody: P00952(ARHGAP15 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P00952(ARHGAP15 Antibody) at dilution 1/50. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P00952(ARHGAP15 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

參考文獻(xiàn)

1. **"ARHGAP15 regulates endothelial barrier function by controlling neutrophil recruitment"**

*Authors: Müller WA, et al.*

摘要:研究利用ARHGAP15抗體探討該蛋白在內(nèi)皮細(xì)胞屏障中的作用,發(fā)現(xiàn)其通過調(diào)節(jié)RhoA活性抑制中性粒細(xì)胞遷移,維持血管通透性。

2. **"ARHGAP15 suppresses glioblastoma invasion by modulating Rho GTPase signaling"**

*Authors: Li Y, et al.*

摘要:通過ARHGAP15抗體進(jìn)行免疫印跡分析,揭示其在膠質(zhì)母細(xì)胞瘤中下調(diào)Rac1/Cdc42活性,抑制腫瘤細(xì)胞侵襲和轉(zhuǎn)移。

3. **"Loss of ARHGAP15 promotes colorectal cancer metastasis via activating Wnt/β-catenin pathway"**

*Authors: Zhang H, et al.*

摘要:研究采用ARHGAP15抗體檢測結(jié)直腸癌組織中的表達(dá)水平,發(fā)現(xiàn)其低表達(dá)通過激活Wnt通路促進(jìn)癌細(xì)胞遷移,與患者不良預(yù)后相關(guān)。

4. **"ARHGAP15 deficiency enhances hematopoietic stem cell mobilization in mice"**

*Authors: Cancelas JA, et al.*

摘要:通過ARHGAP15敲除模型及抗體染色,證明該蛋白通過調(diào)控Rho激酶活性影響造血干細(xì)胞從骨髓向血液的動(dòng)員過程。

       

背景信息

The ARHGAP15 antibody is a research tool designed to detect and study the ARHGAP15 protein, a member of the Rho GTPase-activating protein (RhoGAP) family. ARHGAP15 functions as a negative regulator of Rho GTPases, particularly Rac1 and Cdc42. by enhancing their intrinsic GTPase activity to promote the inactive GDP-bound state. This regulation influences cytoskeletal dynamics, cell migration, and signaling pathways critical for immune responses, neuronal development, and cancer progression. ARHGAP15 is highly expressed in hematopoietic cells, including neutrophils and macrophages, where it modulates immune cell functions such as phagocytosis and chemotaxis. Dysregulation of ARHGAP15 has been implicated in inflammatory diseases, neurodegenerative disorders, and tumor metastasis.

The antibody enables researchers to investigate ARHGAP15's expression patterns, subcellular localization, and interactions through techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its specificity and validation in experimental models (e.g., human, mouse) make it valuable for elucidating ARHGAP15's roles in physiological and pathological contexts. Recent studies highlight its potential as a biomarker or therapeutic target, particularly in cancers where Rho GTPase signaling is aberrant. However, functional diversity across tissues and species necessitates careful experimental design when using this reagent. Continued research with ARHGAP15 antibodies may uncover novel mechanisms underlying cell motility, immune regulation, and disease pathways.

       
關(guān)鍵字: ARHGAP15抗體;ARHGAP15;ARHGAP15 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (3年) 注冊(cè)資本 50萬(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會(huì)員
  • 公司成立:3年
  • 注冊(cè)資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥1280
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