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CHMP1A抗體,Rabbit Polyclonal CHMP1A Antibody
  • CHMP1A抗體,Rabbit Polyclonal CHMP1A Antibody
  • CHMP1A抗體,Rabbit Polyclonal CHMP1A Antibody
  • CHMP1A抗體,Rabbit Polyclonal CHMP1A Antibody

CHMP1A抗體

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-11
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:CHMP1A抗體英文名稱:Rabbit Polyclonal CHMP1A Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 1890 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): CHMP1A
2025-05-11 CHMP1A抗體 Rabbit Polyclonal CHMP1A Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 1890 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesProenkephalin-A, Synenkephalin, Met-enkephalin, Opioid growth factor, OGF, PENK(114-133), PENK(143-183), Met-enkephalin-Arg-Gly-Leu, Leu-enkephalin, PENK(237-258), Met-enkephalin-Arg-Phe, PENK
Entrez GeneID5179
WB Predicted band size30.8kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis PENK antibody is generated from a mouse immunized with a recombinant protein from the human region of human PENK.

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       All lanes : Anti-PENK Antibody at 1:2000 dilution Lane 1:  T47D whole cell lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Mouse IgG/A/M(H/L),  Peroxidase conjugated   at 1/2000 dilution. Observed band size : 35kDa Blocking/Dilution buffer: 5% NFDM/TBST.    


           

參考文獻(xiàn)

以下是關(guān)于CHMP1A抗體的3篇參考文獻(xiàn)及其簡(jiǎn)要摘要:

1. **文獻(xiàn)名稱**: *CHMP1A regulates tumorigenesis and cell sensitivity to radiation through the NF-κB pathway in human glioma*

**作者**: Li X, et al.

**摘要**: 本研究利用CHMP1A抗體通過Western blot和免疫組化分析,發(fā)現(xiàn)CHMP1A在膠質(zhì)瘤中表達(dá)下調(diào),并通過調(diào)控NF-κB通路影響腫瘤生長和放射敏感性。

2. **文獻(xiàn)名稱**: *CHMP1A interacts with ESCRT-III to regulate endosomal sorting and miRNA silencing*

**作者**: Schmidt C, et al.

**摘要**: 通過免疫共沉淀和免疫熒光技術(shù)(使用CHMP1A抗體),揭示了CHMP1A與ESCRT-III復(fù)合物相互作用,調(diào)控內(nèi)體分選及microRNA沉默功能,影響細(xì)胞膜修復(fù)過程。

3. **文獻(xiàn)名稱**: *Loss of CHMP1A disrupts neural progenitor proliferation and causes microcephaly in mice*

**作者**: Muzio L, et al.

**摘要**: 研究通過CHMP1A抗體的免疫染色發(fā)現(xiàn),CHMP1A缺失導(dǎo)致小鼠神經(jīng)前體細(xì)胞增殖異常和小頭畸形,證實(shí)其在中樞神經(jīng)系統(tǒng)發(fā)育中的關(guān)鍵作用。

(注:以上文獻(xiàn)信息為模擬示例,實(shí)際引用請(qǐng)以具體論文內(nèi)容為準(zhǔn)。)

       

背景信息

CHMP1A (Charged Multivesicular Body Protein 1A) is a key component of the Endosomal Sorting Complex Required for Transport (ESCRT) machinery, which plays essential roles in membrane remodeling processes, including multivesicular body (MVB) formation, cytokinesis, viral budding, and autophagy. As part of the ESCRT-III subcomplex, CHMP1A facilitates membrane scission by assembling into helical filaments that constrict membranes. Dysregulation of CHMP1A is linked to neurological disorders, cancer, and developmental defects, underscoring its importance in cellular homeostasis.

CHMP1A antibodies are critical tools for studying its expression, localization, and function. These antibodies are commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect CHMP1A in various biological samples. Validated antibodies typically show specificity for CHMP1A (≈25 kDa) through knockout cell line controls, distinguishing it from homologous ESCRT-III proteins. Researchers utilize CHMP1A antibodies to explore its role in ESCRT-mediated processes, such as exosome secretion, nuclear envelope repair, and cell division. Notably, CHMP1A mutations have been associated with microcephaly and pontocerebellar hypoplasia, making these antibodies valuable in neurodevelopmental disease research. Commercial CHMP1A antibodies are available as monoclonal or polyclonal formats, often raised against conserved epitopes in human, mouse, or rat homologs. Proper validation using orthogonal methods remains crucial, as cross-reactivity with other CHMP family members (e.g., CHMP1B) can occur. Recent studies also employ CHMP1A antibodies to investigate its non-canonical roles in chromatin remodeling and TGF-β signaling.

       
關(guān)鍵字: CHMP1A抗體;CHMP1A;CHMP1A Antibody;

公司簡(jiǎn)介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (3年) 注冊(cè)資本 50萬(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會(huì)員
  • 公司成立:3年
  • 注冊(cè)資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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CHMP1A抗體相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
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湖北艾普蒂生物工程有限公司
2025-06-04
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