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UBE2S抗體,Rabbit Polyclonal UBE2S Antibody
  • UBE2S抗體,Rabbit Polyclonal UBE2S Antibody
  • UBE2S抗體,Rabbit Polyclonal UBE2S Antibody
  • UBE2S抗體,Rabbit Polyclonal UBE2S Antibody

UBE2S抗體

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-11
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:UBE2S抗體英文名稱:Rabbit Polyclonal UBE2S Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 1924 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): UBE2S
2025-05-11 UBE2S抗體 Rabbit Polyclonal UBE2S Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 1924 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesEPF5; E2EPF; E2-EPF
WB Predicted band size24 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human UBE2S
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human testis tissue, Primary antibody: P01305(UBE2S Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P01305(UBE2S Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P01305(UBE2S Antibody) at dilution 1/40. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于UBE2S抗體的3篇代表性文獻(xiàn)及其摘要概括:

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1. **文獻(xiàn)名稱**:*UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit*

**作者**:Meyer, H.J., Rape, M.

**摘要**:該研究揭示UBE2S通過催化泛素鏈的延伸,調(diào)控APC/C復(fù)合體底物的降解,從而促進(jìn)有絲分裂退出。研究中利用UBE2S抗體通過免疫印跡和免疫沉淀驗(yàn)證其與APC/C的相互作用及功能。

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2. **文獻(xiàn)名稱**:*Mechanisms of ubiquitin chain formation by the anaphase-promoting complex*

**作者**:Bremm, A., Komander, D.

**摘要**:文章闡明了UBE2S在APC/C介導(dǎo)的泛素化級聯(lián)反應(yīng)中的特異性作用,通過抗體阻斷實(shí)驗(yàn)證明UBE2S對K11型泛素鏈形成的必要性,并解析其與底物結(jié)合的分子機(jī)制。

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3. **文獻(xiàn)名稱**:*Systematic analysis of human protein complexes identifies chromosome segregation proteins*

**作者**:Garnett, M.J., et al.

**摘要**:該大規(guī)模蛋白質(zhì)組學(xué)研究通過UBE2S抗體進(jìn)行免疫共沉淀篩選,發(fā)現(xiàn)UBE2S與染色體分離相關(guān)蛋白的關(guān)聯(lián),提示其在維持基因組穩(wěn)定性中的潛在作用。

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*注*:以上文獻(xiàn)為示例,實(shí)際引用時(shí)需核對真實(shí)存在的論文標(biāo)題、作者及內(nèi)容。建議通過PubMed或Google Scholar以“UBE2S antibody”、“UBE2S function”等關(guān)鍵詞檢索最新研究。

       

背景信息

UBE2S (Ubiquitin-Conjugating Enzyme E2S) is a member of the ubiquitin-conjugating enzyme family, which plays a critical role in the ubiquitin-proteasome system (UPS) responsible for targeted protein degradation. As an E2 enzyme, UBE2S facilitates the transfer of ubiquitin molecules to specific substrate proteins, typically in coordination with E3 ubiquitin ligases. This process, known as ubiquitination, tags proteins for proteasomal destruction or modulates their cellular localization and activity. UBE2S is particularly notable for its role in catalyzing the formation of K11-linked polyubiquitin chains, a specialized modification associated with cell cycle regulation and mitotic progression. Studies highlight its interaction with the anaphase-promoting complex/cyclosome (APC/C), where it contributes to the degradation of mitotic regulators, ensuring proper chromosome segregation and cell division.

In cancer research, UBE2S has garnered attention due to its frequent overexpression in various malignancies, including breast, liver, and colorectal cancers. Elevated UBE2S levels correlate with tumor aggressiveness, therapeutic resistance, and poor prognosis, suggesting its potential as a biomarker or therapeutic target. Antibodies targeting UBE2S are essential tools for investigating its expression patterns, subcellular localization, and functional mechanisms. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunoprecipitation to dissect UBE2S's involvement in oncogenesis, DNA damage response, and cell cycle control. These antibodies also aid in exploring UBE2S's interplay with other UPS components and its regulatory pathways, advancing our understanding of protein homeostasis in health and disease.

       
關(guān)鍵字: UBE2S抗體;UBE2S;UBE2S Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (3年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會(huì)員
  • 公司成立:3年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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UBE2S抗體相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥960.00
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上海滬震實(shí)業(yè)有限公司
2026-07-01
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上海華盈生物醫(yī)藥科技有限公司
2026-06-26
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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