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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P01601(NR1D1 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P01601(NR1D1 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

The nuclear receptor subfamily 1 group D member 1 (NR1D1. also known as Rev-erbα) is a ligand-regulated transcription factor that plays a pivotal role in regulating circadian rhythms, metabolism, and inflammatory responses. As a member of the nuclear receptor superfamily, NR1D1 binds to specific DNA response elements and recruits corepressors to suppress target gene expression. It is a key component of the molecular clock machinery, forming interlocking feedback loops with other circadian regulators like BMAL1 and CLOCK. NR1D1 also interacts with metabolic pathways, influencing lipid/glucose homeostasis and mitochondrial function.

NR1D1 antibodies are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques such as Western blotting, immunohistochemistry, chromatin immunoprecipitation (ChIP), and immunofluorescence to investigate NR1D1's roles in circadian biology, metabolic disorders, cancer, and cardiovascular diseases. Many antibodies target specific epitopes, such as the N-terminal or ligand-binding domains, with validation often including knockout/knockdown controls to confirm specificity.

Research using NR1D1 antibodies has revealed its therapeutic potential, as pharmacological activation or inhibition of NR1D1 impacts circadian synchronization and metabolic syndromes. These studies highlight its dual regulatory functions and crosstalk with other nuclear receptors (e.g., ROR proteins), making NR1D1 a focal point in chronobiology and disease mechanism research.

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