| 中文名稱:STAG1抗體 | 英文名稱:Rabbit Polyclonal STAG1 Antibody |
| 品牌: 艾普蒂 | 產(chǎn)地: 武漢 |
| 保存條件: Stored at -20°C for 2054 year. Avoid repeated freeze / thaw cycles. | 產(chǎn)品類別: 抗體 |
| 重組: 否 | 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA |
| 種屬反應性: Human,Mouse,Rat | 宿主: Rabbit |
| 偶聯(lián)物: 無 | 靶點: STAG1 |
| WB | 咨詢技術(shù) | Human,Mouse,Rat |
| IF | 咨詢技術(shù) | Human,Mouse,Rat |
| IHC | 1/150-1/300 | Human,Mouse,Rat |
| ICC | 技術(shù)咨詢 | Human,Mouse,Rat |
| FCM | 咨詢技術(shù) | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SA1; MRD47; SCC3A |
| WB Predicted band size | 144 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human STAG1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 293T and Hela cell lysates, Primary antibody: P01764(STAG1 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute
The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P01764(STAG1 Antibody) at dilution 1/150. (Original magnification: ×200)
The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P01764(STAG1 Antibody) at dilution 1/150. (Original magnification: ×200)
以下是3-4條關(guān)于STAG1抗體的參考文獻示例(注:內(nèi)容為模擬概括,具體文獻請核實數(shù)據(jù)庫):
1. **文獻名稱**:*STAG1 regulates cohesin complex integrity for mitotic chromosome dynamics*
**作者**:Smith A, et al.
**摘要**:研究通過STAG1抗體進行免疫沉淀和染色質(zhì)免疫共沉淀(ChIP-seq),揭示了STAG1在維持黏連蛋白復合體穩(wěn)定性及調(diào)控有絲分裂染色體分離中的關(guān)鍵作用。
2. **文獻名稱**:*STAG1 mutations in human neurodevelopmental disorders and cancer*
**作者**:Li J, et al.
**摘要**:利用STAG1抗體進行Western blot和免疫熒光分析,發(fā)現(xiàn)STAG1功能缺失突變與自閉癥譜系障礙及某些癌癥的基因組不穩(wěn)定性相關(guān)。
3. **文獻名稱**:*Cohesin subunit STAG1 is required for hematopoietic stem cell maintenance*
**作者**:Wang Y, et al.
**摘要**:通過STAG1抗體敲低實驗和小鼠模型,證明STAG1對造血干細胞自我更新和分化至關(guān)重要,其缺失導致白血病發(fā)生風險增加。
4. **文獻名稱**:*STAG1-mediated chromatin interactions modulate transcriptional regulation*
**作者**:Garcia E, et al.
**摘要**:使用STAG1抗體的Hi-C和3D基因組分析,揭示了STAG1通過介導染色質(zhì)環(huán)形成調(diào)控基因表達的分子機制。
(注意:以上文獻信息為示例性質(zhì),實際引用請以具體論文為準。)
The STAG1 antibody is a research tool used to detect STAG1 (Stromal Antigen 1), a core component of the cohesin complex, which plays critical roles in chromosome organization, sister chromatid cohesion, and transcriptional regulation. Cohesin, composed of SMC1. SMC3. RAD21. and STAG subunits, ensures proper chromosome segregation during cell division. STAG1. one of two stromal antigen paralogs (STAG1 and STAG2), contributes to cohesin's dynamic DNA-binding activity and tissue-specific functions. Dysregulation of STAG1 is linked to developmental disorders and cancers, particularly through mutations affecting cohesin's role in gene expression and genome stability.
STAG1 antibodies are widely employed in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to study its localization, interactions, and expression levels. Researchers use these antibodies to explore STAG1's involvement in mitotic regulation, DNA repair, and 3D chromatin architecture. Notably, STAG1-specific antibodies help distinguish its functions from STAG2. which shares structural similarities but exhibits distinct roles in certain cancers, such as myeloid malignancies. Recent studies also highlight STAG1's potential role in neurodevelopmental disorders, making its antibody a key reagent for mechanistic investigations. Validation of antibody specificity remains crucial due to homology among STAG family proteins.
| 成立日期 | 2024-06-24 (3年) | 注冊資本 | 50萬(元) |
| 員工人數(shù) | 1-10人 | 年營業(yè)額 | ¥ 100萬以內(nèi) |
| 主營行業(yè) | 中間體,化學試劑 | 經(jīng)營模式 | 貿(mào)易,工廠,試劑,定制,服務 |
| 產(chǎn)品名稱 | 價格 | 公司名稱 | 報價日期 | |
|---|---|---|---|---|
| 詢價 |
上海切爾齊生物科技有限公司
|
2025-05-16 | ||
| 詢價 |
VIP4年
|
維百奧(北京)生物科技有限公司
|
2026-07-30 | |
| ¥1800 |
VIP2年
|
費雪(杭州)醫(yī)學研究有限公司
|
2026-07-27 | |
| ¥1280 |
湖北艾普蒂生物工程有限公司
|
2025-06-04 |