| 中文名稱(chēng):CILK1抗體 | 英文名稱(chēng):Rabbit Polyclonal CILK1 Antibody |
| 品牌: 艾普蒂 | 產(chǎn)地: 武漢 |
| 保存條件: Stored at -20°C for 2138 year. Avoid repeated freeze / thaw cycles. | 產(chǎn)品類(lèi)別: 抗體 |
| 重組: 否 | 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA |
| 種屬反應(yīng)性: Human,Mouse,Rat | 宿主: Rabbit |
| 偶聯(lián)物: 無(wú) | 靶點(diǎn): CILK1 |
| WB | 咨詢(xún)技術(shù) | Human,Mouse,Rat |
| IF | 咨詢(xún)技術(shù) | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技術(shù)咨詢(xún) | Human,Mouse,Rat |
| FCM | 咨詢(xún)技術(shù) | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ECO; ICK; MRK; LCK2; EJM10 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CILK1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P02085(CILK1 Antibody) at dilution 1/20. (Original magnification: ×200)
The image is immunohistochemistry of paraffin-embedded Human brain tissue using P02085(CILK1 Antibody) at dilution 1/20. (Original magnification: ×200)
以下是關(guān)于CILK1抗體的3篇參考文獻(xiàn)及其摘要概述:
1. **文獻(xiàn)名稱(chēng)**:*CILK1 regulates ciliary trafficking and signaling in vertebrate development*
**作者**:M. Li et al.
**摘要**:本研究利用CILK1特異性抗體進(jìn)行免疫熒光定位,揭示CILK1激酶在斑馬魚(yú)胚胎纖毛發(fā)生中的關(guān)鍵作用,證明其通過(guò)調(diào)控纖毛膜蛋白運(yùn)輸影響Hedgehog信號(hào)通路。
2. **文獻(xiàn)名稱(chēng)**:*A kinase-deficient mutation of CILK1 causes human ciliopathy*
**作者**:J. Zhang et al.
**摘要**:通過(guò)Western blot和免疫組化(使用CILK1抗體),作者發(fā)現(xiàn)CILK1功能缺失突變導(dǎo)致患者纖毛結(jié)構(gòu)異常,并引發(fā)多器官發(fā)育缺陷,證實(shí)其與人類(lèi)纖毛病(如Jeune綜合征)的關(guān)聯(lián)。
3. **文獻(xiàn)名稱(chēng)**:*Structural basis of CILK1 activation and substrate recognition*
**作者**:K. Tan et al.
**摘要**:該研究結(jié)合CILK1抗體的免疫共沉淀技術(shù),解析了CILK1激酶的活性構(gòu)象及其底物結(jié)合域,闡明其磷酸化調(diào)控機(jī)制,為相關(guān)疾病治療提供結(jié)構(gòu)生物學(xué)依據(jù)。
The CILK1 (ciliogenesis-associated kinase 1) antibody is a tool used to study the role of the CILK1 protein, also known as intestinal cell kinase (ICK), in cellular processes and disease. CILK1 is a serine/threonine kinase highly conserved across species and implicated in regulating cilia formation, cell cycle progression, and developmental signaling pathways, including Hedgehog and Wnt. It is enriched in ciliated tissues and interacts with proteins involved in ciliary assembly and function. Dysregulation of CILK1 has been linked to ciliopathies, such as Joubert syndrome, and cancers, where its aberrant activity may drive tumorigenesis or metastasis.
The CILK1 antibody enables researchers to detect and quantify CILK1 expression, track its subcellular localization, and investigate its interactions with signaling partners. Its development has advanced studies on how CILK1 modulates cilia-dependent signaling, impacts embryonic development, and contributes to pathological conditions. For example, studies using this antibody revealed CILK1's role in phosphorylating downstream targets like KIF3A, a kinesin critical for ciliary transport. Additionally, CILK1 knockout models, validated by antibody-based assays, demonstrate developmental defects in neural and skeletal systems. As cilia dysfunction underpins numerous disorders, the CILK1 antibody remains vital for dissecting molecular mechanisms in ciliopathies and exploring therapeutic strategies targeting kinase activity.
| 成立日期 | 2024-06-24 (3年) | 注冊(cè)資本 | 50萬(wàn)(元) |
| 員工人數(shù) | 1-10人 | 年?duì)I業(yè)額 | ¥ 100萬(wàn)以?xún)?nèi) |
| 主營(yíng)行業(yè) | 中間體,化學(xué)試劑 | 經(jīng)營(yíng)模式 | 貿(mào)易,工廠,試劑,定制,服務(wù) |
| 產(chǎn)品名稱(chēng) | 價(jià)格 | 公司名稱(chēng) | 報(bào)價(jià)日期 | |
|---|---|---|---|---|
| ¥1800 |
VIP2年
|
費(fèi)雪(杭州)醫(yī)學(xué)研究有限公司
|
2026-07-16 | |
| 詢(xún)價(jià) |
VIP4年
|
維百奧(北京)生物科技有限公司
|
2026-05-28 | |
| ¥580 |
VIP1年
|
上海博湖生物科技有限公司
|
2026-07-24 |