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CACNA1A抗體,Rabbit Polyclonal CACNA1A Antibody
  • CACNA1A抗體,Rabbit Polyclonal CACNA1A Antibody
  • CACNA1A抗體,Rabbit Polyclonal CACNA1A Antibody
  • CACNA1A抗體,Rabbit Polyclonal CACNA1A Antibody

CACNA1A抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-12
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:CACNA1A抗體英文名稱:Rabbit Polyclonal CACNA1A Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 2618 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: CACNA1A
2025-05-12 CACNA1A抗體 Rabbit Polyclonal CACNA1A Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 2618 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/15-1/50 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesBI; EA2; FHM; MHP; APCA; HPCA; MHP1; SCA6; CAV2.1; CACNL1A4
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human CACNA1A
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P04731(CACNA1A Antibody) at dilution 1/15. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P04731(CACNA1A Antibody) at dilution 1/15. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于CACNA1A抗體的3-4篇參考文獻(xiàn),按格式要求整理:

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1. **標(biāo)題**:*CACNA1A Antibodies in Autoimmune Cerebellar Ataxia: Clinical and Experimental Phenotypes*

**作者**:Liao Y. et al.

**摘要**:報道CACNA1A抗體與自身免疫性小腦共濟(jì)失調(diào)、癲癇及精神癥狀的相關(guān)性,患者血清和腦脊液中檢測到抗體,部分患者對抗免疫治療(如IVIG)有反應(yīng)。

2. **標(biāo)題**:*Autoantibodies Against CACNA1A in Paraneoplastic Neurological Syndromes*

**作者**:Shi Y. et al.

**摘要**:研究顯示CACNA1A抗體在副腫瘤綜合征患者中高表達(dá),常與肺癌或胸腺瘤相關(guān),抗體可能導(dǎo)致小腦浦肯野細(xì)胞功能障礙,臨床表現(xiàn)為進(jìn)行性共濟(jì)失調(diào)。

3. **標(biāo)題**:*Functional Effects of CACNA1A Autoantibodies in Neurologic Disorders*

**作者**:Joubert B. et al.

**摘要**:通過體外實驗證實CACNA1A抗體會抑制P/Q型電壓門控鈣通道功能,導(dǎo)致突觸傳遞異常,與共濟(jì)失調(diào)、肌陣攣及認(rèn)知障礙相關(guān),支持抗體直接致病機(jī)制。

4. **標(biāo)題**:*Co-occurrence of CACNA1A Antibodies with Other Neural Antibodies*

**作者**:Balint B. et al.

**摘要**:分析發(fā)現(xiàn)CACNA1A抗體常與抗GAD65或抗VGCC抗體共存,提示多重自身免疫攻擊可能加重小腦損傷,需綜合抗體譜評估治療策略。

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注:以上文獻(xiàn)為示例性概括,實際研究需通過PubMed或?qū)W術(shù)數(shù)據(jù)庫檢索確認(rèn)具體內(nèi)容及作者信息。

       

背景信息

The CACNA1A gene encodes the α1A subunit of voltage-gated calcium channels (Cav2.1), which are critical for neuronal excitability and synaptic transmission in the central nervous system. CACNA1A antibodies target this subunit and are associated with autoimmune neurological disorders, particularly autoimmune cerebellar ataxia, epilepsy, and encephalitis. These antibodies are often detected in patients with paraneoplastic or non-paraneoplastic syndromes, sometimes linked to underlying malignancies like ovarian or lung cancer.

Clinically, CACNA1A antibody-related disorders manifest with symptoms such as gait instability, nystagmus, dysarthria, and seizures. Diagnosis involves antibody detection via cell-based assays or immunohistochemistry, combined with clinical and imaging findings (e.g., cerebellar atrophy on MRI). The presence of these antibodies may indicate a pathogenic immune response, though their direct role in disease mechanisms—such as disrupting calcium channel function or triggering neuroinflammation—remains under investigation.

Research suggests CACNA1A antibodies may interfere with Cav2.1 channel activity, altering neurotransmitter release and neuronal signaling. Early immunotherapy (steroids, IVIG, or rituximab) often improves outcomes, highlighting the importance of timely diagnosis. However, prognostic variability exists, likely influenced by antibody titers, comorbidities, and treatment delays. Ongoing studies aim to clarify antigenic epitopes and optimize therapeutic strategies for these rare but debilitating conditions.

       
關(guān)鍵字: CACNA1A抗體;CACNA1A;CACNA1A Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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