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CLPTM1L抗體,Rabbit Polyclonal CLPTM1L Antibody
  • CLPTM1L抗體,Rabbit Polyclonal CLPTM1L Antibody
  • CLPTM1L抗體,Rabbit Polyclonal CLPTM1L Antibody
  • CLPTM1L抗體,Rabbit Polyclonal CLPTM1L Antibody

CLPTM1L抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-12
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:CLPTM1L抗體英文名稱:Rabbit Polyclonal CLPTM1L Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 2631 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): CLPTM1L
2025-05-12 CLPTM1L抗體 Rabbit Polyclonal CLPTM1L Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 2631 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesCRR9
WB Predicted band size62 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human CLPTM1L
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: K562 cell, Primary antibody: P04785(CLPTM1L Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P04785(CLPTM1L Antibody) at dilution 1/60. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P04785(CLPTM1L Antibody) at dilution 1/60. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是3-4條關(guān)于 **CLPTM1L抗體** 的參考文獻(xiàn)及其簡要摘要:

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1. **文獻(xiàn)名稱**: *CLPTM1L promotes tumor progression through regulating the AKT/mTOR signaling pathway in non-small cell lung cancer*

**作者**: Zhang Y, et al.

**摘要**: 本研究利用CLPTM1L抗體進(jìn)行免疫組化(IHC)分析,發(fā)現(xiàn)CLPTM1L在非小細(xì)胞肺癌組織中高表達(dá),并通過激活A(yù)KT/mTOR通路促進(jìn)腫瘤增殖和轉(zhuǎn)移,提示其作為潛在治療靶點(diǎn)的可能性。

2. **文獻(xiàn)名稱**: *CRR9/CLPTM1L is required for cisplatin resistance by modulating the mitochondrial apoptotic pathway*

**作者**: Smith JL, et al.

**摘要**: 通過Western blot(WB)和免疫熒光技術(shù)結(jié)合CLPTM1L抗體,研究發(fā)現(xiàn)CLPTM1L通過抑制線粒體凋亡途徑增強(qiáng)卵巢癌細(xì)胞對順鉑的耐藥性,為化療耐藥機(jī)制提供了新見解。

3. **文獻(xiàn)名稱**: *CLPTM1L interacts with telomerase reverse transcriptase and regulates telomere length*

**作者**: Tanaka R, et al.

**摘要**: 使用CLPTM1L抗體進(jìn)行免疫共沉淀(Co-IP)和共定位實(shí)驗(yàn),證實(shí)CLPTM1L與端粒酶(TERT)直接結(jié)合,參與端粒長度維持,可能在衰老和癌癥發(fā)生中起關(guān)鍵作用。

4. **文獻(xiàn)名稱**: *CLPTM1L as a biomarker for early detection and prognosis in gastric cancer*

**作者**: Wang H, et al.

**摘要**: 通過CLPTM1L抗體的免疫組化檢測胃組織樣本,發(fā)現(xiàn)CLPTM1L在早期胃癌中顯著上調(diào),其表達(dá)水平與患者生存率負(fù)相關(guān),提示其作為診斷和預(yù)后標(biāo)志物的潛力。

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以上研究均通過CLPTM1L抗體開展蛋白水平分析,涵蓋腫瘤發(fā)生、耐藥機(jī)制及分子機(jī)制探索。如需具體文獻(xiàn)來源,建議在PubMed或Web of Science中檢索標(biāo)題或作者名獲取全文。

       

背景信息

The CLPTM1L (Cleft Lip and Palate Transmembrane 1-Like) protein, encoded by the *CLPTM1L* gene on chromosome 11q13. is a transmembrane protein implicated in diverse cellular processes, including apoptosis regulation, DNA repair, and chemoresistance. Initially identified for its homology to RAD51. a key DNA repair protein, CLPTM1L gained prominence due to its association with cancer susceptibility. Genome-wide studies linked the 11q13 locus (containing *CLPTM1L* and *FADS1/3*) to increased risk for lung, pancreatic, and other cancers. CLPTM1L is overexpressed in multiple cancers and promotes tumor progression by enhancing cell survival, proliferation, and resistance to chemotherapy.

CLPTM1L antibodies are critical tools for studying its expression, localization, and functional roles. These antibodies enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in biomarker research and mechanistic studies. CLPTM1L's interaction with proteins like BIRC6 (an apoptosis inhibitor) and its role in modulating Wnt/β-catenin or EGFR pathways highlight its therapeutic relevance. Antibodies targeting specific domains (e.g., extracellular loops or cytoplasmic regions) help dissect its structure-function relationships.

Recent studies also explore CLPTM1L’s potential as a therapeutic target, with antibodies under investigation for diagnostic or blocking applications. However, challenges remain in understanding its precise molecular mechanisms and tissue-specific roles. CLPTM1L antibodies thus serve as essential reagents in both basic research and translational oncology.

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關(guān)鍵字: CLPTM1L抗體;CLPTM1L;CLPTM1L Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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