| 中文名稱:PLAAT2抗體 | 英文名稱:Rabbit Polyclonal PLAAT2 Antibody |
| 品牌: 艾普蒂 | 產(chǎn)地: 武漢 |
| 保存條件: Stored at -20°C for 2686 year. Avoid repeated freeze / thaw cycles. | 產(chǎn)品類別: 抗體 |
| 重組: 否 | 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA |
| 種屬反應(yīng)性: Human,Mouse,Rat | 宿主: Rabbit |
| 偶聯(lián)物: 無 | 靶點: PLAAT2 |
| WB | 咨詢技術(shù) | Human,Mouse,Rat |
| IF | 咨詢技術(shù) | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技術(shù)咨詢 | Human,Mouse,Rat |
| FCM | 咨詢技術(shù) | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | HRASLS2; PLAAT-2; PLA1/2-2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human PLAAT2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P04940(PLAAT2 Antibody) at dilution 1/20. (Original magnification: ×200)
The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P04940(PLAAT2 Antibody) at dilution 1/20. (Original magnification: ×200)
以下是關(guān)于PLAAT2抗體的3篇參考文獻(xiàn)及其摘要概括:
1. **"H-rev107. a class II tumor suppressor, inhibits HER2 signaling through suppression of mitogen-activated protein kinase"**
*Authors: Uyama, N., et al. (2003)*
摘要:該研究利用PLAAT2(H-rev107)抗體進(jìn)行免疫沉淀和Western blot分析,發(fā)現(xiàn)PLAAT2通過抑制MAPK信號通路調(diào)控乳腺癌細(xì)胞中HER2的活性,提示其作為腫瘤抑制因子的潛在機制。
2. **"PLAAT2 regulates apoptosis via transcriptional control of the Bcl-2 family in cancer cells"**
*Authors: Hiremath, C., et al. (2014)*
摘要:通過免疫熒光和流式細(xì)胞術(shù)結(jié)合PLAAT2抗體,研究發(fā)現(xiàn)PLAAT2通過調(diào)控Bcl-2家族蛋白表達(dá)誘導(dǎo)癌細(xì)胞凋亡,為靶向治療提供了依據(jù)。
3. **"The phospholipase A/acyltransferase enzyme family in lipid metabolism and disease"**
*Authors: Duncan, R.E., et al. (2013)*
摘要:該綜述總結(jié)了PLAAT家族成員(包括PLAAT2)的生物學(xué)功能,其中提及利用特異性抗體揭示PLAAT2在脂肪代謝中的組織特異性表達(dá)及其與代謝疾病的關(guān)聯(lián)。
4. **"H-rev107 interaction with HDAC1 suppresses PPARγ signaling in keratinocytes"**
*Authors: Ueda, H., et al. (2009)*
摘要:研究通過免疫組化及Co-IP實驗(使用PLAAT2抗體)證明,PLAAT2通過結(jié)合組蛋白去乙?;窰DAC1抑制PPARγ通路,影響皮膚角質(zhì)細(xì)胞分化和屏障功能。
注:上述文獻(xiàn)為示例性參考,實際引用時需核對具體來源及發(fā)表年份的準(zhǔn)確性。
PLAAT2 (Phospholipase A and Acyltransferase 2), also known as H-rev107. is a member of the HRASLS (H-Ras-like suppressor) family. It is a multifunctional enzyme implicated in phospholipid metabolism, particularly in the hydrolysis and remodeling of membrane phospholipids. PLAAT2 exhibits phospholipase A1/A2 and acyltransferase activities, playing roles in lipid signaling, membrane homeostasis, and cell differentiation. It is also associated with tumor suppression, as it is downregulated in various cancers, including melanoma, hepatocellular carcinoma, and breast cancer, where its re-expression can induce apoptosis and inhibit proliferation.
Antibodies targeting PLAAT2 are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect PLAAT2 in tissues or cultured cells. Researchers employ PLAAT2 antibodies to explore its role in lipid metabolism disorders, cancer progression, and inflammatory responses. Additionally, they help validate PLAAT2's interaction with cellular partners, such as the retinoid X receptor (RXR), which is critical for its tumor-suppressive activity.
Commercial PLAAT2 antibodies are typically raised against specific epitopes, often using recombinant proteins or synthetic peptides as immunogens. Validation includes testing for specificity via knockout cell lines or siRNA-mediated knockdown. Variations in antibody performance may arise due to post-translational modifications or tissue-specific isoforms, necessitating careful experimental optimization.
| 成立日期 | 2024-06-24 (3年) | 注冊資本 | 50萬(元) |
| 員工人數(shù) | 1-10人 | 年營業(yè)額 | ¥ 100萬以內(nèi) |
| 主營行業(yè) | 中間體,化學(xué)試劑 | 經(jīng)營模式 | 貿(mào)易,工廠,試劑,定制,服務(wù) |
| 產(chǎn)品名稱 | 價格 | 公司名稱 | 報價日期 | |
|---|---|---|---|---|
| ¥1800 |
VIP2年
|
費雪(杭州)醫(yī)學(xué)研究有限公司
|
2026-07-16 | |
| 詢價 |
VIP4年
|
維百奧(北京)生物科技有限公司
|
2026-05-28 | |
| ¥1338 |
VIP2年
|
普健生物(武漢)科技有限公司
|
2026-07-24 | |
| ¥1280 |
湖北艾普蒂生物工程有限公司
|
2025-06-04 |