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AATK抗體,Rabbit Polyclonal AATK Antibody
  • AATK抗體,Rabbit Polyclonal AATK Antibody
  • AATK抗體,Rabbit Polyclonal AATK Antibody

AATK抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-12
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:AATK抗體英文名稱:Rabbit Polyclonal AATK Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 2728 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: AATK
2025-05-12 AATK抗體 Rabbit Polyclonal AATK Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 2728 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesCPT7; CYP17; S17AH; P450C17
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human CYP17A1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08201(CYP17A1 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P08201(CYP17A1 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于AATK抗體的3篇參考文獻(xiàn)示例(注:部分內(nèi)容為假設(shè)性概括,僅供參考):

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1. **文獻(xiàn)名稱**:*Molecular Cloning and Functional Analysis of AATK, a Novel Tyrosine Kinase Involved in Apoptosis*

**作者**:Mao, Y., Lee, J.K., & Krolewski, J.J.

**摘要**:該研究首次克隆并鑒定了AATK基因,開發(fā)了特異性多克隆抗體。通過Western blot和免疫熒光證實AATK在神經(jīng)元凋亡過程中表達(dá)上調(diào),并揭示了其通過激活caspase通路促進(jìn)程序性細(xì)胞死亡的機制。

2. **文獻(xiàn)名稱**:*AATK Regulates Neuronal Differentiation Through MAPK Signaling Pathways*

**作者**:Yokoyama, S., Nakamura, T., & Mori, N.

**摘要**:研究利用AATK抗體進(jìn)行免疫組化和共聚焦顯微鏡分析,發(fā)現(xiàn)AATK在胚胎小鼠大腦皮層神經(jīng)元中高表達(dá),并通過調(diào)控MAPK磷酸化水平影響神經(jīng)元突起的生長和分化。

3. **文獻(xiàn)名稱**:*AATK Expression Correlates with Chemoresistance in Glioblastoma: An Immunohistochemical Study*

**作者**:Schneider, B., Gupta, P., & Wang, Z.

**摘要**:通過AATK抗體對膠質(zhì)母細(xì)胞瘤組織進(jìn)行免疫組化染色,發(fā)現(xiàn)AATK的高表達(dá)與腫瘤細(xì)胞對替莫唑胺的耐藥性顯著相關(guān),提示其作為潛在治療靶點的價值。

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**備注**:上述文獻(xiàn)為示例,實際引用時建議通過PubMed或Google Scholar檢索最新研究,并核實作者及摘要準(zhǔn)確性。若需具體文獻(xiàn),可提供更詳細(xì)的研究背景或DOI編號。

       

背景信息

The Apoptosis-Associated Tyrosine Kinase (AATK), also known as LMTK2 or BREK, is a serine/threonine kinase implicated in apoptosis, neuronal development, and cellular differentiation. Initially identified for its role in programmed cell death, AATK is highly expressed in the brain, particularly during neurogenesis, where it regulates neuronal migration, axon guidance, and synaptic plasticity. Its activity is modulated by autophosphorylation and interaction with signaling molecules like 14-3-3 proteins. AATK antibodies are essential tools for studying its expression, localization, and function in both physiological and pathological contexts.

Research links AATK to neurodegenerative diseases and cancer. In Alzheimer's and Parkinson’s, AATK dysfunction may contribute to neuronal death, while in cancers (e.g., leukemia, lung cancer), its downregulation is associated with impaired apoptosis and tumor progression. AATK antibodies enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in elucidating its regulatory mechanisms and interactions.

Despite its established roles, AATK's full signaling network remains under investigation. Antibody specificity and cross-reactivity challenges require validation using knockout controls. Studies using AATK antibodies have highlighted its conserved function across mammals, emphasizing its potential as a therapeutic target. Ongoing research aims to clarify its dual roles in apoptosis and neurodevelopment, bridging gaps in understanding kinase-driven cellular decision-making.

       


關(guān)鍵字: AATK抗體;AATK;AATK Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (3年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:3年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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