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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fat tissue, Primary antibody: P05154(PLIN1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

**Background of PLIN1 Antibody**

Perilipin 1 (PLIN1), a lipid droplet-associated protein, plays a critical role in regulating lipid storage and lipolysis in adipocytes. It is predominantly expressed in white adipose tissue, where it coats lipid droplets and acts as a scaffold to modulate the activity of lipolytic enzymes, such as hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL). PLIN1 phosphorylation, triggered by β-adrenergic signaling, facilitates lipolysis by enabling HSL access to stored triglycerides.

PLIN1 antibodies are essential tools for studying adipocyte biology, lipid metabolism, and metabolic disorders like obesity and insulin resistance. These antibodies enable the detection and localization of PLIN1 via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Researchers use them to investigate PLIN1's role in lipid droplet dynamics, its interaction with other lipolytic regulators, and its expression changes under conditions like fasting, exercise, or pathological states (e.g., lipodystrophy).

Additionally, PLIN1 antibodies have diagnostic relevance, as altered PLIN1 levels correlate with metabolic syndrome and cardiovascular diseases. Their utility extends to exploring therapeutic strategies targeting adipose dysfunction. By enabling precise analysis of PLIN1's structural and functional roles, these antibodies remain pivotal in advancing research on energy homeostasis and metabolic health.