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RAD51抗體,Rabbit Polyclonal RAD51 Antibody
  • RAD51抗體,Rabbit Polyclonal RAD51 Antibody
  • RAD51抗體,Rabbit Polyclonal RAD51 Antibody

RAD51抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-12
QQ交談 微信洽談

產品詳情

中文名稱:RAD51抗體英文名稱:Rabbit Polyclonal RAD51 Antibody
品牌: 艾普蒂產地: 武漢
保存條件: Stored at -20°C for 2768 year. Avoid repeated freeze / thaw cycles.產品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: RAD51
2025-05-12 RAD51抗體 Rabbit Polyclonal RAD51 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 2768 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術 Human,Mouse,Rat
IF咨詢技術 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術咨詢 Human,Mouse,Rat
FCM咨詢技術 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

產品詳情

AliasesRECA; BRCC5; MRMV2; HRAD51; RAD51A; HsRad51; HsT16930
WB Predicted band size37 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human RAD51
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: P05207(RAD51 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P05207(RAD51 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P05207(RAD51 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

參考文獻

以下是3篇關于RAD51抗體的代表性文獻及其摘要:

1. **文獻名稱**: "Homologous recombination and human health: the roles of BRCA1. BRCA2. and RAD51"

**作者**: Prakash R, et al.

**摘要**: 該綜述重點探討RAD51在DNA同源重組修復中的核心作用,并強調針對RAD51的抗體在檢測DNA損傷修復焦點(foci)中的應用,尤其在BRCA突變癌癥模型研究中作為關鍵實驗工具。

2. **文獻名稱**: "RAD51 foci as a biomarker for homologous recombination repair deficiency in cancer"

**作者**: Gogola E, et al.

**摘要**: 研究驗證了使用抗RAD51抗體通過免疫熒光技術定量核內RAD51 foci,可作為評估腫瘤細胞同源重組修復缺陷(HRD)的臨床診斷標志物,為PARP抑制劑治療提供預測依據。

3. **文獻名稱**: "Comparative analysis of commercial RAD51 antibodies for recombination activity assessment"

**作者**: Sato K, et al.

**摘要**: 對比了多種商業(yè)來源的RAD51抗體(如Abcam#ab133534和Cell Signaling#D4B2)在Western blot、免疫組化中的特異性差異,提出標準化抗體選擇對精準檢測RAD51功能活性的必要性。

       

背景信息

The RAD51 antibody is a crucial tool in studying the molecular mechanisms of DNA repair and genome stability. RAD51. a highly conserved protein, plays a central role in homologous recombination repair (HRR) by facilitating strand exchange between damaged DNA and intact homologous sequences. This process is vital for repairing double-strand breaks (DSBs), which, if unrepaired, can lead to genomic instability, carcinogenesis, or cell death. RAD51 forms nucleoprotein filaments on single-stranded DNA, enabling homology search and recombination. Its activity is tightly regulated and often dysregulated in cancers, particularly those with BRCA1/2 mutations (e.g., breast and ovarian cancers), making it a biomarker of "BRCAness" and a predictor of PARP inhibitor sensitivity.

RAD51 antibodies are widely used in research to detect RAD51 expression, localization, and foci formation (indicative of active HRR) through techniques like immunofluorescence, Western blotting, and immunohistochemistry. These antibodies help assess HRR proficiency in cancer cells, study synthetic lethality in BRCA-deficient tumors, and investigate chemoresistance mechanisms. Commercially available RAD51 antibodies are typically raised against conserved epitopes, often validated for cross-reactivity in human, mouse, and rat models. Quality validation includes testing in knockout cell lines to confirm specificity. Recent applications also extend to developmental biology and understanding replication stress responses. Proper antibody selection depends on the experimental model and detection method, emphasizing the need for rigorous validation to ensure accurate interpretation of RAD51's dynamic roles in genome maintenance.

       


關鍵字: RAD51抗體;RAD51;RAD51 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學、質量管理體系。并不斷致力于技術創(chuàng)新,產品創(chuàng)新和管理創(chuàng)新,贏得了國內外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數 1-10人 年營業(yè)額 ¥ 100萬以內
主營行業(yè) 中間體,化學試劑 經營模式 貿易,工廠,試劑,定制,服務
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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