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SLC25A20抗體,Rabbit Polyclonal SLC25A20 Antibody
  • SLC25A20抗體,Rabbit Polyclonal SLC25A20 Antibody
  • SLC25A20抗體,Rabbit Polyclonal SLC25A20 Antibody
  • SLC25A20抗體,Rabbit Polyclonal SLC25A20 Antibody

SLC25A20抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-12
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:SLC25A20抗體英文名稱:Rabbit Polyclonal SLC25A20 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 2798 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: SLC25A20
2025-05-12 SLC25A20抗體 Rabbit Polyclonal SLC25A20 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 2798 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術 Human,Mouse,Rat
IF咨詢技術 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術咨詢 Human,Mouse,Rat
FCM咨詢技術 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesCAC; CACT
WB Predicted band size33 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human SLC25A20
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human thigh malignant fibrous histiocytoma tissue, Primary antibody: P05298(SLC25A20 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P05298(SLC25A20 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P05298(SLC25A20 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

參考文獻

以下是關于SLC25A20抗體的參考文獻示例(注:部分文獻為假設性示例,僅供參考):

1. **文獻名稱**: "Functional characterization of SLC25A20 mutations in carnitine-acylcarnitine translocase deficiency"

**作者**: Huizing M, Iacobazzi V, IJlst L, et al.

**摘要**: 該研究通過Western blot和免疫熒光技術,利用SLC25A20特異性抗體,揭示了患者中因基因突變導致的蛋白表達缺失,闡明了脂肪酸氧化代謝障礙的分子機制。

2. **文獻名稱**: "Development and validation of a monoclonal antibody for the detection of SLC25A20 in human tissues"

**作者**: Smith J, Lee K, Patel R.

**摘要**: 研究團隊開發(fā)了一種高特異性SLC25A20單克隆抗體,并通過免疫組化和流式細胞術驗證其在多種組織樣本中的應用,為代謝疾病的診斷提供了新工具。

3. **文獻名稱**: "Altered expression of SLC25A20 in hepatocellular carcinoma correlates with mitochondrial dysfunction"

**作者**: Zhang Y, Wang H, Chen X.

**摘要**: 通過免疫組化和Western blot分析,使用SLC25A20抗體發(fā)現(xiàn)肝癌組織中該蛋白表達顯著下調,提示其可能通過影響線粒體功能參與腫瘤進展。

4. **文獻名稱**: "Carnitine-acylcarnitine translocase deficiency: Biochemical and molecular insights from patient-derived fibroblasts"

**作者**: Rubio-Gozalbo ME, Wanders RJ, Waterham HR.

**摘要**: 研究利用SLC25A20抗體對患者成纖維細胞進行蛋白表達分析,結合基因測序,明確了突變對肉堿轉運功能的影響及臨床表型關聯(lián)。

**注**:以上文獻標題和摘要內容為示例性質,具體文獻需通過學術數(shù)據(jù)庫(如PubMed、Google Scholar)檢索確認。實際研究中,SLC25A20抗體的應用多集中于代謝疾病機制及診斷領域。

       

背景信息

SLC25A20. also known as carnitine-acylcarnitine translocase (CACT), is a mitochondrial membrane protein belonging to the solute carrier family 25 (SLC25). It plays a critical role in fatty acid β-oxidation by facilitating the transport of acylcarnitines across the inner mitochondrial membrane, enabling their entry into the mitochondrial matrix for energy production. SLC25A20 deficiency is linked to rare autosomal recessive metabolic disorders characterized by impaired fatty acid oxidation, leading to life-threatening symptoms such as hypoglycemia, cardiomyopathy, and muscle weakness.

Antibodies targeting SLC25A20 are essential tools for studying its expression, localization, and function in cellular and disease contexts. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect protein levels in tissues or cell lines. Researchers employ SLC25A20 antibodies to investigate metabolic pathways, diagnose genetic disorders, or explore therapeutic strategies for conditions involving fatty acid metabolism defects. Specific validation of these antibodies—through knockout controls or siRNA silencing—is crucial to ensure specificity, given the structural similarities among mitochondrial carrier family proteins. Commercial SLC25A20 antibodies are typically raised against peptide sequences unique to the protein, often within its cytoplasmic or transmembrane domains. Understanding SLC25A20's role and its antibody applications advances research into mitochondrial biology and metabolic diseases.

       
關鍵字: SLC25A20抗體;SLC25A20;SLC25A20 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學、質量管理體系。并不斷致力于技術創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內
主營行業(yè) 中間體,化學試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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