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TACC2抗體,Rabbit Polyclonal TACC2 Antibody
  • TACC2抗體,Rabbit Polyclonal TACC2 Antibody
  • TACC2抗體,Rabbit Polyclonal TACC2 Antibody
  • TACC2抗體,Rabbit Polyclonal TACC2 Antibody

TACC2抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-12
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:TACC2抗體英文名稱:Rabbit Polyclonal TACC2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 2831 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: TACC2
2025-05-12 TACC2抗體 Rabbit Polyclonal TACC2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 2831 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesAZU-1; ECTACC
WB Predicted band size310 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human TACC2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse muscle tissue, Primary antibody: P05388(TACC2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05388(TACC2 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P05388(TACC2 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

參考文獻

以下是關(guān)于TACC2抗體的3篇參考文獻及其簡要摘要:

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1. **文獻名稱**: *"TACC2 is required for spindle assembly and progression of mitosis in mammalian cells"*

**作者**: Gorjanacz M., et al.

**摘要**: 該研究利用TACC2特異性抗體,通過免疫熒光和Western blot分析,揭示了TACC2在有絲分裂紡錘體組裝中的關(guān)鍵作用,并發(fā)現(xiàn)其缺失導(dǎo)致染色體排列異常和細(xì)胞周期停滯。

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2. **文獻名稱**: *"Interaction of TACC2 with HER2 and its potential role in breast cancer progression"*

**作者**: Lauffart B., et al.

**摘要**: 研究通過免疫共沉淀(Co-IP)和免疫組化技術(shù),結(jié)合TACC2抗體,發(fā)現(xiàn)TACC2與HER2在乳腺癌細(xì)胞中相互作用,可能通過調(diào)控MAPK信號通路促進腫瘤侵襲性。

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3. **文獻名稱**: *"Structural and functional characterization of the TACC2 dimerization domain"*

**作者**: Sadek C.M., et al.

**摘要**: 該研究利用TACC2抗體進行免疫印跡和結(jié)構(gòu)分析,解析了TACC2蛋白的二聚化結(jié)構(gòu)域,并證明其卷曲螺旋區(qū)域?qū)S持蛋白穩(wěn)定性及與其他微管結(jié)合蛋白的相互作用至關(guān)重要。

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4. **文獻名稱**: *"TACC2 expression correlates with poor prognosis in ovarian cancer"*

**作者**: Miyake Y., et al.

**摘要**: 通過免疫組織化學(xué)(IHC)和高通量蛋白組學(xué)分析,結(jié)合TACC2抗體,研究發(fā)現(xiàn)TACC2在卵巢癌組織中高表達,并與患者生存率下降及化療耐藥性顯著相關(guān)。

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這些文獻均通過TACC2抗體在實驗中對蛋白功能、相互作用或臨床意義進行了探討,涵蓋基礎(chǔ)機制到疾病關(guān)聯(lián)研究。

       

背景信息

The TACC2 (Transforming Acidic Coiled-Coil Containing Protein 2) antibody is a tool used to study the TACC2 protein, a member of the conserved TACC family involved in cellular processes such as mitotic spindle organization, transcriptional regulation, and microtubule dynamics. TACC2. encoded by the *TACC2* gene in humans, shares structural homology with TACC1 and TACC3. including a characteristic coiled-coil domain. However, its functional roles appear distinct, with studies linking it to cell cycle progression, differentiation, and cancer biology. TACC2 is expressed in multiple isoforms due to alternative splicing, contributing to tissue-specific functions in the brain, testes, and other organs. Dysregulation of TACC2 has been implicated in cancers, including breast and ovarian tumors, where it may act as an oncogene or tumor suppressor depending on context.

Antibodies targeting TACC2 enable researchers to detect its expression, localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Commercial TACC2 antibodies are typically raised against specific epitopes, often validated using knockout controls to confirm specificity. Challenges in TACC2 research include cross-reactivity with other TACC family members and isoform-specific detection, necessitating careful antibody validation. Current studies focus on elucidating TACC2's role in cancer progression, neuronal development, and its potential as a therapeutic target. Ongoing efforts aim to clarify its molecular mechanisms, particularly in chromatin remodeling complexes and centrosome amplification pathways.

       
關(guān)鍵字: TACC2抗體;TACC2;TACC2 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (3年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:3年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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