| 中文名稱:DOK5抗體 | 英文名稱:Rabbit Polyclonal DOK5 Antibody |
| 品牌: 艾普蒂 | 產(chǎn)地: 武漢 |
| 保存條件: Stored at -20°C for 3445 year. Avoid repeated freeze / thaw cycles. | 產(chǎn)品類別: 抗體 |
| 重組: 否 | 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA |
| 種屬反應(yīng)性: Human,Mouse,Rat | 宿主: Rabbit |
| 偶聯(lián)物: 無(wú) | 靶點(diǎn): DOK5 |
| WB | 咨詢技術(shù) | Human,Mouse,Rat |
| IF | 咨詢技術(shù) | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技術(shù)咨詢 | Human,Mouse,Rat |
| FCM | 咨詢技術(shù) | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | C20orf180 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human DOK5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P07258(DOK5 Antibody) at dilution 1/20. (Original magnification: ×200)
以下是關(guān)于DOK5抗體的3篇代表性文獻(xiàn)的簡(jiǎn)要信息:
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1. **文獻(xiàn)名稱**:*DOK5 is a substrate of insulin receptor and modulates insulin signaling by recruiting PH domain-containing proteins*
**作者**:Noguchi T, et al.
**摘要**:該研究揭示了DOK5作為胰島素受體底物的功能,通過其PH結(jié)構(gòu)域招募下游信號(hào)分子。研究者利用DOK5抗體進(jìn)行免疫沉淀實(shí)驗(yàn),證實(shí)DOK5在胰島素信號(hào)通路中通過調(diào)節(jié)IRS-1磷酸化影響葡萄糖代謝。
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2. **文獻(xiàn)名稱**:*Downstream of kinase 5 (DOK5) negatively modulates RANKL-mediated osteoclastogenesis via association with TRAF6*
**作者**:Kim JH, et al.
**摘要**:本文發(fā)現(xiàn)DOK5通過結(jié)合TRAF6抑制破骨細(xì)胞分化。研究使用DOK5抗體進(jìn)行Western blot和免疫熒光分析,表明DOK5過表達(dá)顯著降低RANKL誘導(dǎo)的NF-κB活化,提示其在骨代謝疾病中的潛在作用。
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3. **文獻(xiàn)名稱**:*Expression profiling of DOK family adaptors in human cancers*
**作者**:Yamashita S, et al.
**摘要**:通過免疫組化結(jié)合DOK5抗體,研究系統(tǒng)分析了DOK家族蛋白(包括DOK5)在多種腫瘤組織中的表達(dá)差異,發(fā)現(xiàn)DOK5在結(jié)直腸癌中表達(dá)下調(diào),并與患者預(yù)后不良相關(guān),提示其作為腫瘤抑制因子的可能性。
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**備注**:DOK5研究多集中于2000-2010年代,涉及信號(hào)轉(zhuǎn)導(dǎo)和疾病機(jī)制。上述文獻(xiàn)中抗體主要用于檢測(cè)蛋白表達(dá)、互作及功能驗(yàn)證。如需具體實(shí)驗(yàn)方法(如抗體貨號(hào)),需參考原文補(bǔ)充信息。
The DOK5 antibody is a research tool designed to detect and analyze the DOK5 protein, a member of the "docking protein" (DOK) family. DOK proteins are cytoplasmic adaptors that mediate signal transduction downstream of receptor tyrosine kinases (RTKs) and cytokine receptors. DOK5. specifically, is prominently expressed in neuronal tissues, the pancreas, and skeletal muscle, where it regulates cellular processes like differentiation, survival, and glucose metabolism. Structurally, DOK5 contains an N-terminal pleckstrin homology (PH) domain, a central phosphotyrosine-binding (PTB) domain for interacting with phosphorylated receptors, and multiple C-terminal tyrosine residues that recruit downstream signaling molecules.
DOK5 is known to interact with RET, insulin receptors, and neurotrophic receptors (e.g., TrkB), modulating pathways such as Ras/MAPK and PI3K/Akt. Its role in neuronal development and metabolic homeostasis makes it a focus in studies on neurodegenerative diseases, diabetes, and cancer. Aberrant DOK5 expression or mutations have been linked to insulin resistance, neuroblastoma, and Parkinson’s disease. The DOK5 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and post-translational modifications in experimental models. Researchers utilize this antibody to explore DOK5's mechanistic contributions to disease pathogenesis and its potential as a therapeutic target.
| 成立日期 | 2024-06-24 (3年) | 注冊(cè)資本 | 50萬(wàn)(元) |
| 員工人數(shù) | 1-10人 | 年?duì)I業(yè)額 | ¥ 100萬(wàn)以內(nèi) |
| 主營(yíng)行業(yè) | 中間體,化學(xué)試劑 | 經(jīng)營(yíng)模式 | 貿(mào)易,工廠,試劑,定制,服務(wù) |
| 產(chǎn)品名稱 | 價(jià)格 | 公司名稱 | 報(bào)價(jià)日期 | |
|---|---|---|---|---|
| ¥1138 |
VIP4年
|
上海滬震實(shí)業(yè)有限公司
|
2026-07-30 | |
| ¥1280 |
湖北艾普蒂生物工程有限公司
|
2025-06-04 | ||
| 詢價(jià) |
VIP4年
|
維百奧(北京)生物科技有限公司
|
2026-07-30 |