| 中文名稱:PDCD6抗體 | 英文名稱:Rabbit Polyclonal PDCD6 Antibody |
| 品牌: 艾普蒂 | 產(chǎn)地: 武漢 |
| 保存條件: Stored at -20°C for 3588 year. Avoid repeated freeze / thaw cycles. | 產(chǎn)品類別: 抗體 |
| 重組: 否 | 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA |
| 種屬反應(yīng)性: Human,Mouse,Rat | 宿主: Rabbit |
| 偶聯(lián)物: 無 | 靶點: PDCD6 |
| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨詢技術(shù) | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技術(shù)咨詢 | Human,Mouse,Rat |
| FCM | 咨詢技術(shù) | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | ALG-2, PEF1B |
| WB Predicted band size | 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human PDCD6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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Gel: 10+12%SDS-PAGE, Lysate: 50 μg, Lane 1-4: Jurkat cells, hela cells, human fetal lung tissue, A549 cells, Primary antibody: P07528(PDCD6 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P07528(PDCD6 Antibody) at dilution 1/30. (Original magnification: ×200)
以下是關(guān)于PDCD6抗體的3篇示例參考文獻(xiàn)(注:文獻(xiàn)信息為模擬示例,建議通過PubMed或Google Scholar驗證實際文獻(xiàn)):
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1. **文獻(xiàn)名稱**: "PDCD6/ALG-2 promotes cisplatin resistance in non-small cell lung cancer by modulating apoptosis and autophagy"
**作者**: Li X, et al.
**摘要**: 研究揭示了PDCD6通過抑制caspase依賴性凋亡通路并激活自噬途徑,增強非小細(xì)胞肺癌對順鉑的耐藥性,提示其作為潛在治療靶點。
2. **文獻(xiàn)名稱**: "Development of a monoclonal antibody targeting PDCD6 for hepatocellular carcinoma diagnosis"
**作者**: Wang Y, et al.
**摘要**: 報道了一種高特異性抗PDCD6單克隆抗體的開發(fā),該抗體在肝細(xì)胞癌組織中顯示高敏感性,可作為早期診斷的生物標(biāo)志物。
3. **文獻(xiàn)名稱**: "Structural insights into PDCD6-ALIX interaction and implications for exosome biogenesis"
**作者**: Suzuki H, et al.
**摘要**: 通過X射線晶體學(xué)解析PDCD6與ALIX蛋白的結(jié)合結(jié)構(gòu),闡明其在細(xì)胞外泌體形成中的分子機制,為靶向干預(yù)提供結(jié)構(gòu)基礎(chǔ)。
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如需具體文獻(xiàn),建議通過關(guān)鍵詞 **"PDCD6 antibody"** 或 **"PDCD6 function"** 在學(xué)術(shù)數(shù)據(jù)庫中檢索最新研究。
PDCD6 (Programmed Cell Death 6), also known as ALG-2 (Apoptosis-Linked Gene 2), is a calcium-binding protein involved in diverse cellular processes, including apoptosis, endoplasmic reticulum stress response, and membrane trafficking. It belongs to the penta-EF-hand protein family and interacts with partners like ALIX and Sec31A through calcium-dependent mechanisms. PDCD6 plays a dual role in apoptosis, acting as either a pro- or anti-apoptotic regulator depending on cellular context and interacting partners. Dysregulation of PDCD6 has been linked to cancers, neurodegenerative diseases, and immune disorders, making it a potential therapeutic or diagnostic target.
PDCD6 antibodies are immunological tools developed to detect and study the expression, localization, and function of PDCD6 in research and clinical settings. These antibodies are typically generated in hosts like rabbits or mice using immunogenic peptides or recombinant PDCD6 protein. They are validated for applications such as Western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. High-quality PDCD6 antibodies help elucidate its role in disease mechanisms, particularly in apoptosis-related pathways and tumor progression. Recent studies also explore PDCD6's interaction networks using these antibodies, providing insights into its regulatory mechanisms in cellular stress responses. Commercial PDCD6 antibodies often undergo rigorous specificity testing, including knockout/knockdown validation, to ensure reliability in experimental models.
| 成立日期 | 2024-06-24 (3年) | 注冊資本 | 50萬(元) |
| 員工人數(shù) | 1-10人 | 年營業(yè)額 | ¥ 100萬以內(nèi) |
| 主營行業(yè) | 中間體,化學(xué)試劑 | 經(jīng)營模式 | 貿(mào)易,工廠,試劑,定制,服務(wù) |
| 產(chǎn)品名稱 | 價格 | 公司名稱 | 報價日期 | |
|---|---|---|---|---|
| ¥3870 |
VIP2年
|
上海西格生物科技有限公司
|
2026-07-24 | |
| ¥1600.00 |
VIP11年
|
北京索萊寶科技有限公司
|
2026-07-23 | |
| 詢價 |
VIP4年
|
武漢佰樂博生物技術(shù)有限公司
|
2026-07-24 | |
| ¥1280 |
湖北艾普蒂生物工程有限公司
|
2025-06-04 |