| 中文名稱:PC抗體 | 英文名稱:Rabbit Polyclonal PC Antibody |
| 品牌: 艾普蒂 | 產(chǎn)地: 武漢 |
| 保存條件: Stored at -20°C for 3591 year. Avoid repeated freeze / thaw cycles. | 產(chǎn)品類別: 抗體 |
| 重組: 否 | 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA |
| 種屬反應(yīng)性: Human,Mouse,Rat | 宿主: Rabbit |
| 偶聯(lián)物: 無 | 靶點(diǎn): PC |
| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨詢技術(shù) | Human,Mouse,Rat |
| IHC | 咨詢技術(shù) | Human,Mouse,Rat |
| ICC | 技術(shù)咨詢 | Human,Mouse,Rat |
| FCM | 咨詢技術(shù) | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | PCB |
| WB Predicted band size | 130 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PC |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, human liver cancer tissue, Primary antibody: P07532(PC Antibody) at dilution 1/100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
以下是關(guān)于PC抗體的3篇代表性文獻(xiàn)及其摘要概括:
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1. **文獻(xiàn)名稱**:*Anti-phosphorylcholine antibodies in atherosclerosis*
**作者**:F. J. Stafforini et al.
**摘要**:研究分析了抗磷酸膽堿(PC)抗體在動(dòng)脈粥樣硬化中的作用,發(fā)現(xiàn)低水平的IgM型抗PC抗體與心血管疾病風(fēng)險(xiǎn)增加相關(guān),提示其可能通過調(diào)控炎癥反應(yīng)發(fā)揮保護(hù)作用。
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2. **文獻(xiàn)名稱**:*Phosphorylcholine-Specific Antibodies as Novel Biomarkers in Systemic Lupus Erythematosus*
**作者**:A. A. Bengtsson et al.
**摘要**:探討了抗PC抗體在系統(tǒng)性紅斑狼瘡(SLE)中的潛在生物標(biāo)志物價(jià)值,發(fā)現(xiàn)患者血清中抗PC抗體水平降低,可能與疾病活動(dòng)度及動(dòng)脈粥樣硬化并發(fā)癥相關(guān)。
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3. **文獻(xiàn)名稱**:*Immunoglobulin M antibodies against phosphorylcholine are inversely related to vascular disease in end-stage renal disease*
**作者**:M. L. Frosteg?rd et al.
**摘要**:通過隊(duì)列研究證明,慢性腎病患者中IgM型抗PC抗體水平較高者心血管事件發(fā)生率較低,支持抗PC抗體在抑制血管炎癥中的保護(hù)性機(jī)制。
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如需更多文獻(xiàn),可進(jìn)一步限定研究領(lǐng)域(如抗PC抗體的檢測(cè)方法或特定疾病關(guān)聯(lián))。
**Background of PC Antibodies**
Phosphorylcholine (PC) antibodies are a subset of natural antibodies primarily of the IgM class, recognized for their role in innate immunity. These antibodies target phosphorylcholine, a molecular epitope found on microbial pathogens (e.g., *Streptococcus pneumoniae*) and oxidized low-density lipoproteins (oxLDL) in atherosclerotic plaques. First identified in the 1970s, PC antibodies are part of the body's first-line defense, bridging innate and adaptive immune responses.
Structurally, PC antibodies bind to PC moieties via conserved antigen-binding regions, enabling broad reactivity. Their production is partly T-cell-independent, arising from B1 B-cells in response to microbial exposure or endogenous danger signals. Functionally, they neutralize pathogens, promote phagocytosis, and modulate inflammation by interacting with C-reactive protein (CRP) or scavenger receptors.
Clinically, low levels of PC antibodies correlate with increased cardiovascular risk, as they help clear oxLDL and apoptotic cells, reducing plaque inflammation. Conversely, altered PC antibody responses are implicated in autoimmune diseases like lupus and rheumatoid arthritis, where their deficiency may exacerbate tissue damage. Recent studies explore their therapeutic potential, including anti-inflammatory agents or biomarkers for disease monitoring. Research continues to unravel their precise mechanisms and applications in immunology and translational medicine.
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| 成立日期 | 2024-06-24 (3年) | 注冊(cè)資本 | 50萬(元) |
| 員工人數(shù) | 1-10人 | 年?duì)I業(yè)額 | ¥ 100萬以內(nèi) |
| 主營行業(yè) | 中間體,化學(xué)試劑 | 經(jīng)營模式 | 貿(mào)易,工廠,試劑,定制,服務(wù) |
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2026-07-16 | |
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