| 中文名稱:PSMD3抗體 | 英文名稱:Rabbit Polyclonal PSMD3 Antibody |
| 品牌: 艾普蒂 | 產(chǎn)地: 武漢 |
| 保存條件: Stored at -20°C for 3610 year. Avoid repeated freeze / thaw cycles. | 產(chǎn)品類別: 抗體 |
| 重組: 否 | 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA |
| 種屬反應(yīng)性: Human,Mouse,Rat | 宿主: Rabbit |
| 偶聯(lián)物: 無 | 靶點: PSMD3 |
| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨詢技術(shù) | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技術(shù)咨詢 | Human,Mouse,Rat |
| FCM | 咨詢技術(shù) | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | S3; P58; RPN3; TSTA2 |
| WB Predicted band size | 61 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human PSMD3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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Gel: 10%SDS-PAGE, Lysate: 50 μg, Lane 1-2: NIH/3T3 cells, human fetal kidney tissue, Primary antibody: P07567(PSMD3 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P07567(PSMD3 Antibody) at dilution 1/25. (Original magnification: ×200)
The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P07567(PSMD3 Antibody) at dilution 1/25. (Original magnification: ×200)
以下是關(guān)于PSMD3抗體的3篇參考文獻(xiàn)示例(注:部分內(nèi)容為示例性概括,具體文獻(xiàn)需通過學(xué)術(shù)數(shù)據(jù)庫驗證):
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1. **文獻(xiàn)名稱**: *PSMD3 as a Prognostic Biomarker in Breast Cancer: Insights from Immunohistochemical Analysis*
**作者**: Li X, Wang Y, et al.
**摘要**: 本研究通過免疫組化(IHC)分析PSMD3在乳腺癌組織中的表達(dá),發(fā)現(xiàn)其高表達(dá)與患者不良預(yù)后相關(guān)。研究使用特異性PSMD3抗體進(jìn)行檢測,驗證了其在腫瘤進(jìn)展中的潛在作用。
2. **文獻(xiàn)名稱**: *Proteasome Subunit PSMD3 Regulates NF-κB Signaling via Ubiquitination*
**作者**: Chen J, Zhang H, et al.
**摘要**: 文章探討PSMD3通過調(diào)控泛素化過程影響NF-κB信號通路的機制。實驗中采用PSMD3抗體進(jìn)行Western blot和免疫共沉淀(Co-IP),證實其與關(guān)鍵蛋白的相互作用。
3. **文獻(xiàn)名稱**: *Development and Validation of a Monoclonal Antibody for PSMD3 in Human Tissues*
**作者**: Tanaka K, Yamamoto S, et al.
**摘要**: 本研究開發(fā)并驗證了一種針對人源PSMD3的高效單克隆抗體。通過ELISA、免疫熒光和流式細(xì)胞術(shù)驗證抗體的特異性,為后續(xù)疾病相關(guān)研究提供了可靠工具。
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**備注**:實際文獻(xiàn)需通過PubMed、Web of Science等平臺檢索確認(rèn)。若研究較少,可擴展至PSMD3功能或相關(guān)通路的研究中提及抗體使用的文獻(xiàn)。
The PSMD3 (Proteasome 26S Subunit, Non-ATPase 3) antibody is a tool used to study the PSMD3 protein, a key component of the 26S proteasome. The 26S proteasome is a multi-subunit complex responsible for ubiquitin-dependent protein degradation, playing a critical role in maintaining cellular homeostasis by regulating protein turnover, cell cycle progression, apoptosis, and stress responses. PSMD3. also known as Rpn3. is part of the 19S regulatory particle (RP) that recognizes ubiquitinated proteins, removes ubiquitin tags, and unfolds substrates for translocation into the proteolytic 20S core.
PSMD3 contains a PCI (Proteasome-COP9-eIF3) domain, which facilitates interactions within the 19S RP and other protein complexes. Its expression is linked to various cellular processes, including DNA repair and signal transduction. Dysregulation of proteasome activity, including PSMD3 function, has been implicated in cancer, neurodegenerative diseases, and autoimmune disorders. For example, elevated PSMD3 levels are observed in certain cancers, correlating with poor prognosis and drug resistance.
Antibodies targeting PSMD3 are essential for investigating its expression, localization, and molecular interactions via techniques like Western blotting, immunohistochemistry, and immunoprecipitation. They also aid in exploring the therapeutic potential of proteasome inhibition in diseases. Research using PSMD3 antibodies contributes to understanding proteasome biology and developing targeted therapies, particularly in oncology.
| 成立日期 | 2024-06-24 (3年) | 注冊資本 | 50萬(元) |
| 員工人數(shù) | 1-10人 | 年營業(yè)額 | ¥ 100萬以內(nèi) |
| 主營行業(yè) | 中間體,化學(xué)試劑 | 經(jīng)營模式 | 貿(mào)易,工廠,試劑,定制,服務(wù) |
| 產(chǎn)品名稱 | 價格 | 公司名稱 | 報價日期 | |
|---|---|---|---|---|
| ¥2964 |
VIP5年
|
上海博爾森生物科技有限公司
|
2026-07-28 | |
| ¥1600.00 |
VIP11年
|
北京索萊寶科技有限公司
|
2026-07-28 | |
| ¥1800 |
VIP2年
|
費雪(杭州)醫(yī)學(xué)研究有限公司
|
2026-07-27 | |
| ¥1280 |
湖北艾普蒂生物工程有限公司
|
2025-06-04 |