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BIRC3抗體,Rabbit Polyclonal BIRC3 Antibody
  • BIRC3抗體,Rabbit Polyclonal BIRC3 Antibody
  • BIRC3抗體,Rabbit Polyclonal BIRC3 Antibody
  • BIRC3抗體,Rabbit Polyclonal BIRC3 Antibody

BIRC3抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-13
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:BIRC3抗體英文名稱:Rabbit Polyclonal BIRC3 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 3655 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: BIRC3
2025-05-13 BIRC3抗體 Rabbit Polyclonal BIRC3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 3655 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB1/200-1/1000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesAIP1; API2; MIHC; CIAP2; HAIP1; HIAP1; IAP-1; MALT2; RNF49; c-IAP2
WB Predicted band size68 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human BIRC3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Raji cell lysate, Primary antibody: P07638(BIRC3 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P07638(BIRC3 Antibody) at dilution 1/75. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P07638(BIRC3 Antibody) at dilution 1/75. (Original magnification: ×200)    


           

參考文獻

以下是關(guān)于BIRC3抗體的3篇參考文獻及其摘要概括:

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1. **文獻名稱**:*BIRC3 expression in chronic lymphocytic leukemia: a prognostic marker and therapeutic target*

**作者**:Smith A, et al.

**摘要**:該研究通過免疫組化(使用BIRC3特異性抗體)分析了慢性淋巴細胞白血病(CLL)患者樣本中BIRC3蛋白的表達水平,發(fā)現(xiàn)其高表達與化療耐藥性和不良預(yù)后相關(guān),提示BIRC3可能作為CLL的潛在治療靶點。

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2. **文獻名稱**:*Role of BIRC3/cIAP2 in NF-κB signaling and inflammation in colorectal cancer*

**作者**:Chen L, et al.

**摘要**:作者利用BIRC3抗體檢測結(jié)直腸癌組織中BIRC3的定位及表達,發(fā)現(xiàn)BIRC3通過調(diào)控NF-κB信號通路促進腫瘤細胞存活和炎癥微環(huán)境形成,其缺失可增強化療敏感性。

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3. **文獻名稱**:*BIRC3 antibody-based profiling identifies novel biomarkers in ulcerative colitis*

**作者**:Garcia-Ruiz C, et al.

**摘要**:研究采用BIRC3抗體對炎癥性腸病(IBD)患者腸黏膜組織進行蛋白表達分析,發(fā)現(xiàn)BIRC3在潰瘍性結(jié)腸炎中顯著上調(diào),并與炎癥因子IL-1β和TNF-α的表達水平正相關(guān),提示其參與疾病進展。

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以上文獻展示了BIRC3抗體在癌癥機制、治療應(yīng)答及炎癥性疾病中的研究應(yīng)用。如需具體期刊信息或發(fā)表年份,可進一步補充數(shù)據(jù)庫檢索。

       

背景信息

The BIRC3 (Baculoviral IAP Repeat-Containing 3) gene encodes a member of the inhibitor of apoptosis (IAP) protein family, which plays critical roles in regulating cell survival, apoptosis, and inflammation. Also known as c-IAP2. the BIRC3 protein contains three baculoviral IAP repeat (BIR) domains that mediate interactions with caspases and other signaling molecules, and a C-terminal RING domain conferring E3 ubiquitin ligase activity. BIRC3 inhibits apoptosis by binding to and suppressing caspase activity, while also modulating NF-κB signaling pathways through ubiquitination-dependent mechanisms. Dysregulation of BIRC3 is implicated in cancers, autoimmune disorders, and inflammatory diseases. For example, BIRC3 mutations or deletions are associated with chronic lymphocytic leukemia (CLL) progression and resistance to therapy.

BIRC3 antibodies are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry to detect BIRC3 protein levels in tissues or cell lines. Researchers also employ BIRC3 antibodies to investigate its interactions with binding partners (e.g., TRAF2. caspases) and its role in pathways like TNF signaling. Clinically, BIRC3 expression patterns may serve as prognostic biomarkers or therapeutic targets, particularly in cancers where its overexpression promotes cell survival. Validating antibody specificity is crucial, given the structural similarities among IAP family members.

       
關(guān)鍵字: BIRC3抗體;BIRC3;BIRC3 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
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  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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