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TMEM67抗體,Rabbit Polyclonal TMEM67 Antibody
  • TMEM67抗體,Rabbit Polyclonal TMEM67 Antibody
  • TMEM67抗體,Rabbit Polyclonal TMEM67 Antibody
  • TMEM67抗體,Rabbit Polyclonal TMEM67 Antibody

TMEM67抗體 新品

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-13
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:TMEM67抗體英文名稱:Rabbit Polyclonal TMEM67 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 3697 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: TMEM67
2025-05-13 TMEM67抗體 Rabbit Polyclonal TMEM67 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 3697 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesMKS3; JBTS6; NPHP11; TNEM67; MECKELIN
WB Predicted band size112 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human TMEM67
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human kidney tissue and A549 cell lysates, Primary antibody: P07720(TMEM67 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07720(TMEM67 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P07720(TMEM67 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

參考文獻

以下是關(guān)于TMEM67抗體的3篇參考文獻的簡要總結(jié)(注:文獻信息為模擬示例,可能需要根據(jù)實際研究調(diào)整):

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1. **文獻名稱**:*TMEM67 mutations cause Meckel-Gruber syndrome with dynamic ciliary localization of the mutant protein*

**作者**:Smith UM, et al.

**摘要**:本研究通過免疫熒光技術(shù),使用TMEM67特異性抗體揭示了突變蛋白在患者細胞中的異常亞細胞定位。發(fā)現(xiàn)TMEM67突變導(dǎo)致纖毛結(jié)構(gòu)缺陷,并干擾Hedgehog信號通路,為Meckel綜合征的病理機制提供了證據(jù)。

2. **文獻名稱**:*Antibody-based profiling of TMEM67 in ciliopathy models reveals its interaction with ciliary membrane proteins*

**作者**:Garcia-Gonzalo FR, et al.

**摘要**:研究利用TMEM67抗體進行免疫共沉淀和質(zhì)譜分析,發(fā)現(xiàn)TMEM67與多種纖毛膜蛋白互作,并證實其在纖毛發(fā)生和信號轉(zhuǎn)導(dǎo)中的關(guān)鍵作用??贵w驗證實驗顯示TMEM67在腎臟和視網(wǎng)膜組織高表達。

3. **文獻名稱**:*Development of a novel monoclonal antibody against TMEM67 for diagnostic applications in Joubert syndrome*

**作者**:Zhang L, et al.

**摘要**:報道了一種新型TMEM67單克隆抗體的開發(fā)與驗證。通過Western blot和免疫組化證實其高特異性,并應(yīng)用于Joubert綜合征患者的臨床樣本檢測,顯示突變患者的TMEM67表達水平顯著降低。

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如需真實文獻,建議在PubMed或Google Scholar中以“TMEM67 antibody”為關(guān)鍵詞檢索,并篩選涉及抗體應(yīng)用(如定位、功能研究或診斷)的論文。

       

背景信息

The TMEM67 antibody is a crucial tool for studying the transmembrane protein 67 (TMEM67), also known as meckelin, which plays a pivotal role in ciliary function and cellular signaling. TMEM67 is a key component of the primary cilium, a sensory organelle involved in developmental pathways like Hedgehog and Wnt. Mutations in the TMEM67 gene are linked to ciliopathies, including Joubert syndrome, Meckel-Gruber syndrome, and COACH syndrome, characterized by renal, hepatic, and neurological abnormalities.

TMEM67 antibodies are designed to detect and analyze the expression, localization, and interactions of the TMEM67 protein in various tissues and cell types. These antibodies are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to investigate ciliary structure-function relationships and disease mechanisms. Researchers employ TMEM67 antibodies to explore its role in ciliogenesis, cell polarity, and tissue development, as well as its interactions with other ciliary proteins like RPGRIP1L and CC2D2A.

The development of specific, high-affinity TMEM67 antibodies has advanced diagnostics and research into ciliopathies, enabling precise detection of protein variants and post-translational modifications. Commercial antibodies are typically validated in human, mouse, or rat models, with applications spanning basic research, biomarker discovery, and therapeutic target validation. Understanding TMEM67's molecular pathology through antibody-based studies continues to shed light on therapeutic strategies for cilia-related disorders.

       
關(guān)鍵字: TMEM67抗體;TMEM67;TMEM67 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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