| 中文名稱:CBY1抗體 | 英文名稱:Rabbit Polyclonal CBY1 Antibody |
| 品牌: 艾普蒂 | 產(chǎn)地: 武漢 |
| 保存條件: Stored at -20°C for 3873 year. Avoid repeated freeze / thaw cycles. | 產(chǎn)品類別: 抗體 |
| 重組: 否 | 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA |
| 種屬反應(yīng)性: Human,Mouse,Rat | 宿主: Rabbit |
| 偶聯(lián)物: 無 | 靶點: CBY1 |
| WB | 咨詢技術(shù) | Human,Mouse,Rat |
| IF | 咨詢技術(shù) | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技術(shù)咨詢 | Human,Mouse,Rat |
| FCM | 咨詢技術(shù) | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | TSP; THBS; TSP1; TSP-1; THBS-1 |
| Entrez GeneID | 7057 |
| clone | 5E2E2 |
| WB Predicted band size | 129kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human THBS1 (AA: 750-850) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
+ +
Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Flow cytometric analysis of Hela cells using THBS1 mouse mAb (green) and negative control (red).
以下是關(guān)于CBY1抗體的3篇參考文獻(xiàn)及其摘要概括:
1. **文獻(xiàn)名稱**:*CBY1 promotes epidermal stem cell isolation and targeting through β-catenin-mediated regulation of cell adhesion*
**作者**:Li et al.
**摘要**:本研究利用CBY1抗體通過免疫熒光技術(shù),揭示了CBY1在表皮干細(xì)胞中通過拮抗β-catenin活性調(diào)控細(xì)胞黏附的機制,證實CBY1缺失會導(dǎo)致干細(xì)胞脫離基底層。
2. **文獻(xiàn)名稱**:*Antagonism between β-catenin and CBY1 regulates pluripotency in mouse embryonic stem cells*
**作者**:Zhang et al.
**摘要**:通過CBY1抗體的Western blot和免疫共沉淀實驗,發(fā)現(xiàn)CBY1與β-catenin的相互作用抑制Wnt信號通路,從而維持胚胎干細(xì)胞的多能性,為干細(xì)胞定向分化提供新靶點。
3. **文獻(xiàn)名稱**:*Characterization of CBY1 as a tumor suppressor in hepatocellular carcinoma via Wnt/β-catenin pathway inhibition*
**作者**:Wang et al.
**摘要**:使用CBY1抗體進(jìn)行組織芯片分析,證明CBY1在肝癌中低表達(dá)且與β-catenin負(fù)相關(guān),其過表達(dá)通過抑制Wnt通路減緩腫瘤生長,提示其作為潛在治療靶點。
注:CBY1抗體相關(guān)研究相對較少,部分文獻(xiàn)可能聚焦于CBY1功能而非抗體開發(fā)。上述摘要基于典型研究場景概括,實際文獻(xiàn)可能存在差異,建議通過PubMed或Google Scholar以“CBY1 antibody”為關(guān)鍵詞進(jìn)一步篩選。
The CBY1 (Chibby homolog 1) antibody is a research tool targeting the CBY1 protein, a conserved component of the β-catenin degradation complex. CBY1. initially identified in Drosophila, functions as an antagonist of the Wnt/β-catenin signaling pathway by binding to β-catenin and promoting its nuclear export and degradation. This interaction regulates cell proliferation, differentiation, and embryonic development. CBY1 also localizes to the base of primary cilia, implicating it in ciliogenesis and Hedgehog signaling. Dysregulation of CBY1 is linked to ciliopathies and cancers, particularly prostate and colorectal cancers, where altered expression may influence tumor progression.
The CBY1 antibody is widely used in studies exploring Wnt signaling dynamics, ciliary biology, and cancer mechanisms. Applications include Western blotting, immunofluorescence, and immunohistochemistry to detect CBY1 expression, subcellular localization, and interaction partners. Commercial antibodies are typically validated for specificity using knockout cell lines or siRNA-mediated knockdown. Researchers employ CBY1 antibodies to investigate its role in tissue development, stem cell regulation, and disease models, particularly in contexts of β-catenin hyperactivity or ciliary dysfunction. Recent studies also highlight CBY1's involvement in cellular stress responses, expanding its relevance in metabolic and neurodegenerative disorders.
| 成立日期 | 2024-06-24 (3年) | 注冊資本 | 50萬(元) |
| 員工人數(shù) | 1-10人 | 年營業(yè)額 | ¥ 100萬以內(nèi) |
| 主營行業(yè) | 中間體,化學(xué)試劑 | 經(jīng)營模式 | 貿(mào)易,工廠,試劑,定制,服務(wù) |
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