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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse thymus tissue, Primary antibody: P08042(AIFM3 Antibody) at dilution 1/240, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08042(AIFM3 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P08042(AIFM3 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The AIFM3 (Apoptosis-Inducing Factor Mitochondrion-associated 3) antibody is a tool used to detect and study the AIFM3 protein, a member of the apoptosis-inducing factor (AIF) family. Unlike its well-characterized homolog AIFM1. which plays a critical role in caspase-independent apoptosis, AIFM3 has distinct structural and functional features. It contains a mitochondrial localization signal and a flavin-binding domain, suggesting involvement in redox processes. However, its precise biological role remains less defined. Studies indicate AIFM3 may participate in oxidative phosphorylation, mitochondrial homeostasis, or DNA damage response, but its apoptotic function appears context-dependent and differs from AIFM1.

AIFM3 antibodies are primarily utilized in research to investigate its expression patterns, subcellular localization, and interactions. These antibodies enable techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding in the exploration of AIFM3's role in diseases. For instance, altered AIFM3 expression has been observed in certain cancers and reproductive system disorders, implying potential therapeutic or diagnostic relevance. Additionally, AIFM3 antibodies help clarify its relationship with mitochondrial dynamics and cellular stress responses. Despite progress, further studies are needed to fully unravel its mechanisms and validate its utility as a biomarker or drug target.