| 中文名稱:CLIP1抗體 | 英文名稱:Rabbit Polyclonal CLIP1 Antibody |
| 品牌: 艾普蒂 | 產(chǎn)地: 武漢 |
| 保存條件: Stored at -20°C for 3972 year. Avoid repeated freeze / thaw cycles. | 產(chǎn)品類別: 抗體 |
| 重組: 否 | 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA |
| 種屬反應(yīng)性: Human,Mouse,Rat | 宿主: Rabbit |
| 偶聯(lián)物: 無 | 靶點(diǎn): CLIP1 |
| WB | 咨詢技術(shù) | Human,Mouse,Rat |
| IF | 咨詢技術(shù) | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技術(shù)咨詢 | Human,Mouse,Rat |
| FCM | 咨詢技術(shù) | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | RSN; CLIP; CYLN1; CLIP170; CLIP-170 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CLIP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08164(CLIP1 Antibody) at dilution 1/20. (Original magnification: ×200)
以下是關(guān)于CLIP1抗體的3-4篇參考文獻(xiàn)及其簡要摘要:
1. **"Cytoplasmic linker protein CLIP-170 regulates microtubule dynamics and transport in neurons"**
*Schwarz, N., et al. (2015). Journal of Cell Biology.*
摘要:該研究通過使用CLIP1特異性抗體,揭示了CLIP-170在神經(jīng)元軸突運(yùn)輸中的作用,表明其通過調(diào)控微管穩(wěn)定性影響囊泡運(yùn)輸和突觸功能。
2. **"CLIP-170 coordinates cell motility by regulating microtubule crosstalk with actin cytoskeleton"**
*Wong, R.W., et al. (2018). Molecular Biology of the Cell.*
摘要:作者利用CLIP1抗體進(jìn)行免疫熒光實(shí)驗(yàn),發(fā)現(xiàn)CLIP-170通過介導(dǎo)微管與肌動蛋白骨架的交互,促進(jìn)癌細(xì)胞的侵襲性遷移,為腫瘤轉(zhuǎn)移機(jī)制提供新見解。
3. **"A role for CLIP-1 in mitotic spindle organization and chromosome segregation"**
*Lee, S.H., et al. (2020). Nature Communications.*
摘要:研究通過CLIP1抗體的Western blot和免疫沉淀技術(shù),證明CLIP-1在有絲分裂中調(diào)控紡錘體組裝及染色體分離,缺失會導(dǎo)致基因組不穩(wěn)定性。
4. **"CLIP1 regulates autophagy through microtubule-mediated vesicle transport"**
*Chen, X., et al. (2022). Cell Reports.*
摘要:利用CLIP1抗體敲低實(shí)驗(yàn),揭示CLIP-1通過協(xié)調(diào)自噬體與微管的關(guān)聯(lián),影響溶酶體降解途徑,為自噬相關(guān)疾病治療提供潛在靶點(diǎn)。
注:以上文獻(xiàn)信息為模擬示例,實(shí)際引用時(shí)需核實(shí)具體文章是否存在及細(xì)節(jié)準(zhǔn)確性。
The CLIP1 (CAP-Gly Domain Containing Linker Protein 1) antibody is a tool used to study the function and localization of the CLIP1 protein, a key regulator of microtubule dynamics in eukaryotic cells. CLIP1. also known as CLIP-170. belongs to the family of cytoplasmic linker proteins (CLIPs) that mediate interactions between microtubules and intracellular organelles or signaling molecules. It contains an N-terminal CAP-Gly domain, which enables binding to microtubule plus ends, and coiled-coil regions facilitating dimerization and interactions with other proteins like dynein/dynactin complexes.
CLIP1 plays critical roles in vesicular transport, cell polarity, mitosis, and cytoskeletal organization by promoting microtubule stabilization and guiding directional cargo movement. Its dysfunction has been linked to neurological disorders, cancer metastasis, and impaired immune cell trafficking. The CLIP1 antibody is widely used in techniques such as immunofluorescence, Western blotting, and immunoprecipitation to detect CLIP1 expression levels, subcellular distribution, and protein-protein interactions. Researchers employ it to investigate mechanisms underlying microtubule-dependent processes, disease pathologies, or drug effects on cytoskeletal dynamics. Commercial CLIP1 antibodies are typically raised against specific epitopes (e.g., human CLIP1 N-terminal regions) and validated for cross-reactivity in various model organisms, ensuring versatility in both basic and translational studies.
| 成立日期 | 2024-06-24 (3年) | 注冊資本 | 50萬(元) |
| 員工人數(shù) | 1-10人 | 年?duì)I業(yè)額 | ¥ 100萬以內(nèi) |
| 主營行業(yè) | 中間體,化學(xué)試劑 | 經(jīng)營模式 | 貿(mào)易,工廠,試劑,定制,服務(wù) |
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|---|---|---|---|---|
| ¥1600.00 |
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2025-06-04 |