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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P08213(DACH2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08213(DACH2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The DACH2 antibody is a research tool used to detect and study the Dachshund homolog 2 (DACH2) protein, a member of the Dachshund gene family. DACH2 is a transcription regulatory protein involved in cell fate determination, organogenesis, and developmental processes. It interacts with DNA-binding proteins and chromatin modifiers to regulate gene expression, often acting as a co-repressor for transcription factors like AP-1 or SRC. Structurally, it contains a conserved Dachshund domain for protein-protein interactions and a DNA-binding domain.

Research on DACH2 has focused on its roles in sex development, neurogenesis, and cancer. It is implicated in ovarian development and female reproductive functions, with mutations linked to disorders like premature ovarian insufficiency. In cancer, DACH2 may act as a tumor suppressor or oncogene, depending on context, with altered expression observed in breast, ovarian, and prostate cancers. Studies also explore its involvement in signaling pathways, including TGF-β and Notch.

The DACH2 antibody enables detection of protein expression, localization, and interactions via techniques like Western blot, immunohistochemistry, and immunofluorescence. It aids in elucidating DACH2's dual roles in development and disease, particularly its tissue-specific functions and potential as a therapeutic target. However, research challenges persist due to limited isoform-specific antibodies and incomplete understanding of its regulatory mechanisms across biological contexts.