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CD48抗體,Rabbit Polyclonal CD48 Antibody
  • CD48抗體,Rabbit Polyclonal CD48 Antibody
  • CD48抗體,Rabbit Polyclonal CD48 Antibody
  • CD48抗體,Rabbit Polyclonal CD48 Antibody

CD48抗體

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-14
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:CD48抗體英文名稱:Rabbit Polyclonal CD48 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 5105 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): CD48
2025-05-14 CD48抗體 Rabbit Polyclonal CD48 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 5105 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesBCM1; BLAST; hCD48; mCD48; BLAST1; SLAMF2; MEM-102
WB Predicted band size28 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human CD48
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: 231, K562, Jurkat and Raji cell lysates, Primary antibody: P09870(CD48 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09870(CD48 Antibody) at dilution 1/95. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于CD48抗體的3篇代表性文獻(xiàn)摘要(注:文獻(xiàn)信息為模擬示例,實(shí)際需根據(jù)具體論文調(diào)整):

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1. **文獻(xiàn)名稱**:*CD48 functions as a co-stimulatory molecule in T cell activation*

**作者**:Springer TA, et al.

**摘要**:該研究揭示了CD48通過與CD2相互作用,在T細(xì)胞活化中發(fā)揮共刺激信號作用,增強(qiáng)免疫突觸的形成并促進(jìn)T細(xì)胞受體介導(dǎo)的激活。

2. **文獻(xiàn)名稱**:*CD48 is a novel ligand for the macrophage adhesion receptor CD244*

**作者**:Gonzalez-Cabrera PJ, et al.

**摘要**:研究發(fā)現(xiàn)CD48與巨噬細(xì)胞表面的CD244(2B4)結(jié)合,調(diào)控自然殺傷(NK)細(xì)胞和巨噬細(xì)胞的細(xì)胞毒性反應(yīng),在抗病毒免疫中起關(guān)鍵作用。

3. **文獻(xiàn)名稱**:*Targeting CD48 in B-cell malignancies: A therapeutic strategy*

**作者**:Stojanovic A, et al.

**摘要**:該文獻(xiàn)提出CD48在B細(xì)胞惡性腫瘤中高表達(dá),并通過抗體阻斷實(shí)驗(yàn)證實(shí)靶向CD48可抑制腫瘤細(xì)胞增殖,為血液腫瘤治療提供新思路。

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如需具體文獻(xiàn),建議通過PubMed或Google Scholar檢索關(guān)鍵詞“CD48 antibody” + “immune response/therapy/signaling”進(jìn)一步篩選。

       

背景信息

CD48 is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein belonging to the immunoglobulin superfamily, primarily expressed on hematopoietic cells, including T cells, B cells, natural killer (NK) cells, dendritic cells, and macrophages. It functions as a ligand for CD244 (2B4) and CD2. playing roles in immune cell adhesion, activation, and signal modulation. CD48 is involved in regulating immune responses, such as NK cell-mediated cytotoxicity and T cell co-stimulation, and has been implicated in infectious diseases, autoimmune disorders, and cancer.

Antibodies targeting CD48 are valuable tools for studying its biological functions and therapeutic potential. Monoclonal anti-CD48 antibodies have been developed to investigate its role in immune regulation and disease pathogenesis. For example, they help elucidate mechanisms in viral infections (e.g., HIV, where CD48 may facilitate viral spread) or tumor microenvironments (e.g., modulating immune evasion). In cancer, CD48 expression on malignant cells or immune cells may serve as a biomarker or therapeutic target. Preclinical studies explore anti-CD48 antibodies for blocking pathogenic interactions or enhancing immune cell activity. Challenges include balancing specificity and minimizing off-target effects due to CD48’s broad expression. Current research also focuses on combining anti-CD48 with other immunotherapies, such as anti-CD47 or checkpoint inhibitors, to amplify efficacy. Despite being in early stages, CD48 antibodies hold promise for advancing immunotherapy and understanding immune dysregulation.

       
關(guān)鍵字: CD48抗體;CD48;CD48 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會(huì)員
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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