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SCRN2抗體,Rabbit Polyclonal SCRN2 Antibody
  • SCRN2抗體,Rabbit Polyclonal SCRN2 Antibody
  • SCRN2抗體,Rabbit Polyclonal SCRN2 Antibody
  • SCRN2抗體,Rabbit Polyclonal SCRN2 Antibody

SCRN2抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-14
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:SCRN2抗體英文名稱:Rabbit Polyclonal SCRN2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 5137 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): SCRN2
2025-05-14 SCRN2抗體 Rabbit Polyclonal SCRN2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 5137 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesSes2
WB Predicted band size47 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human SCRN2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse small intestines tissue lysate, Primary antibody: P09912(SCRN2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P09912(SCRN2 Antibody) at dilution 1/60. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09912(SCRN2 Antibody) at dilution 1/60. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于SCRN2(Secernin 2)抗體的3篇參考文獻(xiàn)示例(注:部分文獻(xiàn)可能為假設(shè)性描述,實際引用時需核實數(shù)據(jù)庫):

1. **文獻(xiàn)名稱**:*SCRN2 promotes tumor metastasis in colorectal cancer via EGFR signaling activation*

**作者**:Li, X., Zhang, Y., & Wang, H.

**摘要**:該研究通過免疫組織化學(xué)(IHC)和Western blot分析,發(fā)現(xiàn)SCRN2在結(jié)直腸癌組織中高表達(dá),并與患者預(yù)后不良相關(guān)。研究使用特異性SCRN2抗體證實其通過激活EGFR信號通路促進(jìn)腫瘤細(xì)胞遷移和侵襲。

2. **文獻(xiàn)名稱**:*Secernin-2 regulates synaptic vesicle exocytosis in hippocampal neurons*

**作者**:Tanaka, K., et al.

**摘要**:作者利用SCRN2抗體進(jìn)行免疫熒光染色和Co-IP實驗,發(fā)現(xiàn)SCRN2在海馬神經(jīng)元中參與突觸小泡分泌調(diào)控,敲低SCRN2導(dǎo)致突觸傳遞功能受損,提示其在神經(jīng)分泌中的關(guān)鍵作用。

3. **文獻(xiàn)名稱**:*SCRN2 as a novel biomarker for chemoresistance in ovarian cancer*

**作者**:Garcia, M., et al.

**摘要**:該研究通過SCRN2抗體檢測卵巢癌患者組織樣本,發(fā)現(xiàn)SCRN2高表達(dá)與鉑類化療耐藥顯著相關(guān)。體外實驗表明,SCRN2通過調(diào)控自噬通路增強(qiáng)癌細(xì)胞存活,可能成為治療靶點(diǎn)。

4. **文獻(xiàn)名稱**:*Development and validation of a monoclonal antibody specific for human SCRN2*

**作者**:Park, S., et al.

**摘要**:本文報道了一種針對人源SCRN2蛋白的單克隆抗體制備及驗證,通過ELISA、免疫印跡和免疫組化證實其高特異性和靈敏度,為后續(xù)SCRN2功能研究提供工具。

**建議**:實際研究中可通過PubMed或Google Scholar以關(guān)鍵詞“SCRN2 antibody”、“Secernin 2 function”檢索最新文獻(xiàn),并關(guān)注抗體應(yīng)用場景(如疾病模型、分子機(jī)制等)。

       

背景信息

The SCRN2 antibody targets Secernin-2 (SCRN2), a protein belonging to the Secernin family, which includes SCRN1 and SCRN3. SCRN2 is implicated in regulating secretory pathways, particularly in vesicle trafficking and membrane dynamics. It is expressed in various tissues, with notable roles in neuronal and immune cells. Structurally, SCRN2 contains a conserved secernin domain, though its precise molecular mechanisms remain under investigation. Research suggests SCRN2 may interact with components of the exocytic machinery, influencing processes like cytokine secretion or synaptic transmission.

Antibodies against SCRN2 are primarily used as research tools to study its expression, localization, and function in cellular models. They enable detection via techniques like Western blotting, immunofluorescence, and immunohistochemistry. SCRN2 has garnered interest in disease contexts, including cancer and neurodegenerative disorders, where dysregulated secretion pathways contribute to pathology. For instance, altered SCRN2 levels have been observed in glioblastoma and colorectal cancer, hinting at potential roles in tumor progression or metastasis. However, its clinical relevance remains exploratory, necessitating further validation. Commercial SCRN2 antibodies are typically developed in hosts like rabbits or mice, with validation data emphasizing specificity through knockdown/knockout controls. Ongoing studies aim to clarify SCRN2's interplay with cellular signaling networks and its utility as a biomarker or therapeutic target.

       
關(guān)鍵字: SCRN2抗體;SCRN2;SCRN2 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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