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PCSK5抗體,Rabbit Polyclonal PCSK5 Antibody
  • PCSK5抗體,Rabbit Polyclonal PCSK5 Antibody
  • PCSK5抗體,Rabbit Polyclonal PCSK5 Antibody
  • PCSK5抗體,Rabbit Polyclonal PCSK5 Antibody

PCSK5抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-14
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:PCSK5抗體英文名稱:Rabbit Polyclonal PCSK5 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 5175 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: PCSK5
2025-05-14 PCSK5抗體 Rabbit Polyclonal PCSK5 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 5175 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

WB Predicted band size69 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human LTA4H
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal brain tissue, Primary antibody: P08487(LTA4H Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P08487(LTA4H Antibody) at dilution 1/30. (Original magnification: ×200)    


           

參考文獻

以下是關(guān)于PCSK5抗體的3篇示例參考文獻(內(nèi)容為示例,建議通過學(xué)術(shù)數(shù)據(jù)庫查詢真實文獻):

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1. **文獻名稱**: *PCSK5 regulates somatic cell reprogramming through TGF-β signaling*

**作者**: Li Y, et al.

**摘要**: 研究利用特異性PCSK5抗體進行免疫沉淀和Western blot分析,發(fā)現(xiàn)PCSK5通過調(diào)控TGF-β通路影響體細胞重編程,抗體被用于檢測蛋白表達及細胞內(nèi)定位。

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2. **文獻名稱**: *Proprotein convertase PCSK5 interacts with cancer-associated fibroblasts in tumor microenvironment*

**作者**: Smith J, et al.

**摘要**: 通過免疫組化(使用抗PCSK5單克隆抗體)和基因沉默實驗,揭示了PCSK5在腫瘤相關(guān)成纖維細胞中的高表達及其對腫瘤侵襲的促進作用。

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3. **文獻名稱**: *Development of a neutralizing antibody against PCSK5 for metabolic disorder therapy*

**作者**: Chen L, et al.

**摘要**: 報道了一種新型中和性PCSK5抗體的開發(fā),通過動物模型驗證其可抑制肝臟脂質(zhì)代謝異常,為代謝性疾病治療提供了潛在策略。

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如需真實文獻,建議通過PubMed或Google Scholar搜索關(guān)鍵詞“PCSK5 antibody”+具體研究領(lǐng)域(如癌癥、代謝疾病等),篩選近年高被引論文。

       

背景信息

The PCSK5 antibody is a research tool targeting proprotein convertase subtilisin/kexin type 5 (PCSK5), a member of the proprotein convertase family responsible for proteolytic activation of precursor proteins. PCSK5. also known as PC5/6. plays critical roles in cleaving inactive proproteins into biologically active forms, including growth factors, hormones, and receptors. It exists in two isoforms (PC5A and PC5B) with distinct cellular localizations and functions, influencing processes like embryonic development, lipid metabolism, and viral entry (e.g., SARS-CoV-2). Dysregulation of PCSK5 is linked to cancers, cardiovascular diseases, and metabolic disorders, making it a potential therapeutic target.

PCSK5 antibodies are widely used to study its expression, localization, and molecular interactions. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Both monoclonal and polyclonal variants exist, with monoclonal antibodies offering higher specificity for specific isoforms or domains (e.g., catalytic or regulatory regions). Challenges include cross-reactivity with other convertases (e.g., PCSK3/Furin) due to structural similarities, necessitating rigorous validation. Recent studies focus on PCSK5's role in tumor progression and its interaction with extracellular matrix components, driving demand for reliable antibodies. Commercial availability from multiple biotech vendors supports diverse research applications, from basic biology to drug discovery.

       
關(guān)鍵字: PCSK5抗體;PCSK5;PCSK5 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (3年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:3年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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