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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P12323(TGM6 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

Transglutaminase 6 (TG6) antibodies are autoantibodies targeting the enzyme transglutaminase 6. a member of the transglutaminase family involved in protein cross-linking. Primarily associated with neurological disorders, TG6 antibodies have gained attention in the context of gluten-related conditions. While transglutaminase 2 (TG2) antibodies are well-established biomarkers for celiac disease, TG6 autoimmunity is often linked to extra-intestinal neurological manifestations, such as gluten ataxia, peripheral neuropathy, and other immune-mediated neurological syndromes.

TG6. expressed predominantly in the central nervous system, shares structural homology with TG2. This molecular mimicry may explain cross-reactivity in some patients with celiac disease who develop neurological symptoms. Research suggests TG6 antibodies may contribute to neuroinflammation by disrupting blood-brain barrier integrity or directly targeting neural tissues. Their detection, typically via ELISA or cell-based assays, aids in diagnosing gluten-related neurological dysfunction, particularly when serological markers for TG2 are absent.

Though less studied than TG2 antibodies, TG6 autoantibodies highlight the systemic nature of gluten sensitivity. Their presence underscores the need for comprehensive evaluation in patients with unexplained neurological deficits and potential gluten intolerance. However, standardized testing protocols and clinical correlations remain areas of ongoing investigation, emphasizing the complexity of autoimmune mechanisms in neuro-gastroenterological disorders.