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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P12339(TSPYL6 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12339(TSPYL6 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The TSPYL6 antibody is a tool used to detect the TSPYL6 protein, encoded by the TSPYL6 gene, which belongs to the testis-specific Y-encoded-like (TSPYL) family. This family shares homology with the TSPY (testis-specific protein Y-encoded) gene and is involved in cell cycle regulation and carcinogenesis. TSPYL6. located on chromosome 2q14.1. is expressed in various tissues, including the brain, testis, and ovaries, and plays roles in cellular differentiation, apoptosis, and chromatin remodeling. Dysregulation of TSPYL6 has been implicated in cancers, such as hepatocellular carcinoma and prostate cancer, where it may act as a tumor suppressor by modulating p53 activity or interacting with cell cycle inhibitors.

The TSPYL6 antibody is commonly utilized in research to study protein expression patterns, subcellular localization (primarily nuclear), and functional mechanisms in both normal and pathological states. It is validated for applications like Western blotting, immunohistochemistry, and immunofluorescence. Studies using this antibody have explored TSPYL6's role in oxidative stress responses, DNA damage repair, and its potential as a biomarker for cancer prognosis. Researchers also investigate its interaction with epigenetic modifiers, such as histone deacetylases, to understand its impact on gene silencing and chromatin dynamics. The antibody's specificity is often confirmed via knockout controls or siRNA-mediated silencing, ensuring reliable detection in experimental models.