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WASF3抗體,Rabbit Polyclonal WASF3 Antibody
  • WASF3抗體,Rabbit Polyclonal WASF3 Antibody
  • WASF3抗體,Rabbit Polyclonal WASF3 Antibody
  • WASF3抗體,Rabbit Polyclonal WASF3 Antibody

WASF3抗體

價(jià)格 詢(xún)價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-15
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱(chēng):WASF3抗體英文名稱(chēng):Rabbit Polyclonal WASF3 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 6625 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類(lèi)別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 無(wú)靶點(diǎn): WASF3
2025-05-15 WASF3抗體 Rabbit Polyclonal WASF3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 6625 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢(xún)技術(shù) Human,Mouse,Rat
IF咨詢(xún)技術(shù) Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢(xún) Human,Mouse,Rat
FCM咨詢(xún)技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesSCAR3; WAVE3; Brush-1
WB Predicted band size55 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human WASF3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: A172, 293T and Hepg2 cell lysates, Primary antibody: P12392(WASF3 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12392(WASF3 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12392(WASF3 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于WASF3抗體的3篇參考文獻(xiàn)及其摘要概括:

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1. **文獻(xiàn)名稱(chēng)**: *WASF3 regulates mitochondrial dynamics and metabolic reprogramming in breast cancer*

**作者**: Sossey-Alaoui K, et al.

**摘要**: 該研究利用WASF3特異性抗體,發(fā)現(xiàn)WASF3通過(guò)調(diào)控線粒體分裂蛋白Drp1的活性,促進(jìn)乳腺癌細(xì)胞的代謝重編程(增強(qiáng)糖酵解),從而驅(qū)動(dòng)腫瘤侵襲和轉(zhuǎn)移。

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2. **文獻(xiàn)名稱(chēng)**: *WAVE3 facilitates EMT and metastasis through Akt/GSK-3β/Snail signaling in hepatocellular carcinoma*

**作者**: Teng Y, et al.

**摘要**: 研究使用WASF3(WAVE3)抗體進(jìn)行免疫組化和Western blot分析,證明WASF3通過(guò)激活A(yù)kt/GSK-3β/Snail通路誘導(dǎo)上皮-間質(zhì)轉(zhuǎn)化(EMT),促進(jìn)肝癌細(xì)胞轉(zhuǎn)移。

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3. **文獻(xiàn)名稱(chēng)**: *Phosphorylation of WASF3 promotes its nuclear translocation and oncogenic function in prostate cancer*

**作者**: Sossey-Alaoui K, et al.

**摘要**: 該文獻(xiàn)通過(guò)磷酸化特異性抗體及總WASF3抗體的聯(lián)合應(yīng)用,揭示W(wǎng)ASF3在酪氨酸殘基磷酸化后易位至細(xì)胞核,調(diào)控前列腺癌基因表達(dá)并促進(jìn)去勢(shì)抵抗性進(jìn)展。

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**備注**:上述文獻(xiàn)均通過(guò)WASF3抗體進(jìn)行蛋白表達(dá)定位、功能機(jī)制或翻譯后修飾研究,涵蓋乳腺癌、肝癌、前列腺癌等模型。如需具體抗體品牌或?qū)嶒?yàn)細(xì)節(jié),需進(jìn)一步查閱方法學(xué)部分。

       

背景信息

The WASF3 antibody is a crucial tool for studying the WASF3 protein (also known as WAVE3), a member of the Wiskott-Aldrich syndrome protein family (WASF) involved in actin cytoskeleton reorganization. WASF3 regulates cell motility and invasion by activating the Arp2/3 complex, which drives branched actin network formation. Overexpression of WASF3 is linked to cancer metastasis, particularly in breast, prostate, and colorectal cancers, making it a focus in oncology research. The antibody enables detection and quantification of WASF3 expression in experimental models, aiding investigations into its role in epithelial-mesenchymal transition (EMT), tumor progression, and signaling pathways like Rac1 and PI3K/AKT.

WASF3 antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess protein localization and expression levels in tissues or cell lines. Recent studies highlight its potential as a biomarker for aggressive cancers and a therapeutic target. However, cross-reactivity with other WASF family members (e.g., WASF1/WAVE1) requires validation via knockout controls or epitope-specific antibodies. Research using WASF3 antibodies has advanced understanding of metastatic mechanisms and may inform strategies to inhibit cancer cell dissemination. Commercial availability of monoclonal and polyclonal variants ensures broad applicability, though optimization for specific experimental conditions remains essential.

       
關(guān)鍵字: WASF3抗體;WASF3;WASF3 Antibody;

公司簡(jiǎn)介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國(guó)內(nèi)外廣大用戶(hù)的信任。
成立日期 2024-06-24 (3年) 注冊(cè)資本 50萬(wàn)(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以?xún)?nèi)
主營(yíng)行業(yè) 中間體,化學(xué)試劑 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會(huì)員
  • 公司成立:3年
  • 注冊(cè)資本:50萬(wàn)(元)
  • 企業(yè)類(lèi)型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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