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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12396(WDR36 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P12396(WDR36 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The WDR36 (WD repeat-containing protein 36) antibody is a tool used to study the WDR36 protein, encoded by the WDR36 gene located on chromosome 5q22.1. WDR36 belongs to the WD-repeat protein family, characterized by conserved motifs facilitating protein-protein interactions. It is implicated in diverse cellular processes, including ribosomal RNA processing, stress response, and apoptosis. WDR36 gained attention due to its association with primary open-angle glaucoma (POAG), a leading cause of irreversible blindness. Genetic studies identified mutations in WDR36 in some POAG patients, though its pathogenic role remains debated.

Antibodies targeting WDR36 are utilized to investigate its expression, localization, and function in ocular tissues, particularly the trabecular meshwork and optic nerve, which are critical in glaucoma pathogenesis. These antibodies enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels and distribution in disease models. Commercial WDR36 antibodies are typically raised in rabbits or mice using immunogenic peptide sequences. Specificity is validated via knockdown/knockout controls or peptide-blocking assays.

Research using WDR36 antibodies aims to clarify its role in glaucoma, including interactions with stress pathways or cellular homeostasis. Despite progress, questions persist about its precise molecular mechanisms in disease, driving ongoing studies to define its contribution to POAG and potential therapeutic targets.