| 價(jià)格 | 詢價(jià) | ||
| 包裝 | 1G | 100G | 1000G |
| 最小起訂量 | 100G |
| 發(fā)貨地 | 江蘇 |
| 更新日期 | 2026-07-28 |
| 中文名稱:鹽酸阿米洛利二水合物 | 英文名稱:Amiloride HCl dihydrate |
| CAS:17440-83-4 | 產(chǎn)品類別: 有機(jī)原料 |
| 別名 | 鹽酸阿米洛利二水合物 |
|---|---|
| 英文別名 | Amilorid hydrochlorid-2-wasser | UNII-FZJ37245UC | AMILORIDE HYDROCHLORIDE [EP IMPURITY] | J-010987 | Q27105756 | Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride dihydrate | DTXSID80169826 | NSC-755847 | HMS1568A15 | 3,5 |
| 規(guī)格或純度 | 10mM in Water |
| 英文名稱 | Amiloride HCl dihydrate |
| 生化機(jī)理 | 鹽酸阿米洛利二水合物是一種強(qiáng)效的上皮鈉通道(ENaC)阻滯劑,用于治療高血壓和充血性心力衰竭。 |
| 儲(chǔ)存溫度 | -80℃儲(chǔ)存 |
| 運(yùn)輸條件 | 超低溫冰袋運(yùn)輸 |
| 作用類型 | 封閉劑 |
| 作用機(jī)制 | 阿米洛利鈉通道,ENaC 阻斷劑 |
| 產(chǎn)品介紹 | Amiloride HCl dihydrate是一種有效的上皮細(xì)胞鈉離子通道抑制劑。An epithelial sodium channel blocker Information Amiloride HCl dihydrate Amiloride HCl dihydrate is a potent epithelial sodium channel (ENaC) blocker, used in the management of hypertension and congestive heart failure. Amiloride also induces the dephosphorylation of P13K (phosphatidylinositol 3-kinase) and PDK-1 (phosphoinositide-dependent kinase-1) kinases along with PTEN (phosphatase and tensin homolog deleted on chromosome 10) and PP1 alpha phosphatases. Amiloride inhibits phosphorylation of kinases and phosphatases by competing with ATP. Amiloride, which causes little or no cytotoxicity by itself, enhances TRAIL-induced apoptosis. Amiloride precludes the alkalinization and in parallel inhibit cellular proliferation. Amiloride directly inhibits autophosphorylation of the EGF receptor. Amiloride significantly enhances recovery to a maximum of 39%, 88%, and 78% for force, +dF/dt, and -dF/dt, respectively. Amiloride, a frequently used inhibitor of Na+/H+ exchange, rapidly inhibits phorbol ester-stimulated protein phosphorylation in vivo and protein kinase C-mediated phosphorylation in vitro, both with potency similar to that with which Amiloride inhibits Na+/H+ exchange. Amiloride blocks phorbol ester-induced adhesion of HL-60 cells (adhesion being a property indicative of the differentiated state), but dimethylamiloride (as well as ethylisopropylamiloride, another very potent amiloride analog) does not. Amiloride inhibits the ouabain-sensitive rate of oxygen consumption (QO2) of a suspension of rabbit intact proximal tubules in the presence of different concentrations of extracellular sodium. |
| 成立日期 | 2014-11-06 (12年) | 注冊(cè)資本 | 100萬人民幣 |
| 員工人數(shù) | 1-10人 | 年?duì)I業(yè)額 | ¥ 100萬以內(nèi) |
| 主營(yíng)行業(yè) | 染料中間體,通用試劑,高純?cè)噭?原料藥,氨基酸及其衍生物 | 經(jīng)營(yíng)模式 | 貿(mào)易,工廠,試劑 |
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