英文名稱Rabbit Anti-GEFT antibody
中文名稱鳥嘌呤核苷酸交換因子GEFT抗體
別 名ARHGEF25; ARHGP_HUMAN; GEFT; p63RhoGEF; Guanine nucleotide exchange factor GEFT; p63RhoGEF ; RAC/CDC42 exchange factor; Rac/Cdc42/Rho exchange factor GEFT; Rho guanine nucleotide exchange factor 25; RhoA/RAC/CDC42 exchange factor; RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT.
研究領(lǐng)域細(xì)胞生物 神經(jīng)生物學(xué) G蛋白偶聯(lián)受體 G蛋白信號
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Rat (predicted: Human,Mouse,Rabbit,Pig,Sheep,Cow)
產(chǎn)品應(yīng)用IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量64kDa
細(xì)胞定位細(xì)胞漿 細(xì)胞膜
性 狀Liquid
濃 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human GEFT: 251-340/580
亞 型IgG
純化方法affinity purified by Protein A
緩 沖 液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMedPubMed
產(chǎn)品介紹GEFT is a 580 amino acid cytoplasmic protein that is highly expressed in excitable tissues such as brain, heart and muscle, and weakly expressed in small intestine, colon, liver, placenta and lung. GEFT may play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. GEFT works as a guanine nucleotide exchange factor for the Rho family of small GTPases and links specifically to G alpha q/11-coupled receptors in Rho A activation. GEFT is an important regulator of processes involved in axon and dendrite formation. Involved in skeletal myogenesis, GEFT seems to be an exchange factor primarily for Rac 1 in neurons. Existing as two alternatively spliced variants, GEFT contains a DH (DBL-homology) domain and a PH domain.
Function:
May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis.
Subunit:
Interacts (via the DH domain) with BVES (via the C-terminus cytoplasmic tail) (By similarity). Interacts with activated GNAQ and GNA11. Interacts with RHOA, CDC42 and RAC1.
Subcellular Location:
Cell membrane. Cytoplasm > myofibril > sarcomere. Highly colocalizes with actin regions.
Tissue Specificity:
Isoform 1 and isoform 2 are highly expressed in excitable tissues, such as brain, heart and muscle. Also detected in kidney and liver.
Similarity:
Contains 1 DH (DBL-homology) domain.
Contains 1 PH domain.
SWISS:
Q86VW2
Gene ID:
115557
關(guān)鍵字： 鳥嘌呤核苷酸交換因子GEFT抗體;鳥嘌呤核苷酸交換因子GEFT抗體;鳥嘌呤核苷酸交換因子;雅吉抗體;一抗;
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