Product Name：SAP15
CAS No.：1403753-45-6
Synonyms：合成抗炎肽Synthetic anti-inflammatory peptide 15
Catalog No.：220P020
Brand：Typeptide Biotech（肽研生物）
Description：SAP15是一種由人類 β-防御素3 設(shè)計(jì)的 15 個(gè)氨基酸組成的合成抗炎肽。SAP15 具有穿透細(xì)胞的能力，并能夠誘導(dǎo)細(xì)胞內(nèi)炎癥的下調(diào)。SAP15 通過抑制 HDAC5 的磷酸化，從而減少 NF-κB p65 的磷酸化，進(jìn)而抑制炎癥反應(yīng)。在 LPS 誘導(dǎo)的巨噬細(xì)胞中，SAP15 能夠抑制 HDAC5 和 NF-κB p65 的磷酸化。此外，SAP15 處理增加了 LPS 誘導(dǎo)的軟骨細(xì)胞中 aggrecan 和 II 型膠原的表達(dá)，并減少了骨鈣素的表達(dá)。SAP15 可用于生物材料的炎癥調(diào)節(jié)和抗炎治療的研究。
SAP15 is a synthetic anti-inflammatory peptide composed of 15 amino acids designed from human beta defence-3. SAP15 has the ability to penetrate cells and induce downregulation of intracellular inflammation. SAP15 reduces the phosphorylation of NF - κ B p65 by inhibiting the phosphorylation of HDAC5, thereby suppressing the inflammatory response. SAP15 can inhibit the phosphorylation of HDAC5 and NF - κ B p65 in LPS induced macrophages. In addition, SAP15 treatment increased the expression of aggrecan and type II collagen in LPS induced chondrocytes, and reduced the expression of osteocalcin. SAP15 can be used for research on inflammation regulation and anti-inflammatory treatment of biomaterials.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | GKCSTRGRKCCRRKK |
Sequence(3-letter code) | H-Gly-Lys-Cys-Ser-Thr-Arg-Gly-Arg-Lys-Cys-Cys-Arg-Arg-Lys-Lys-OH |
Peptide Structure | 
|
Molecular Formula | C68H131N31O18S3 |
Molecular Weight | 1767.16 |
訂購聯(lián)系方式：
南京肽研生物生物科技有限公司
手機(jī)號：19961912513(微信同號)
QQ: 2178255659
郵箱：sales@typeptide.com
聯(lián)系人：顧經(jīng)理
申明：本產(chǎn)品僅供科研使用，不得用于人體。
關(guān)鍵字： SAP15;合成抗炎肽Synthetic anti-;1403753-45-6;多肽;多肽工廠;
肽研生物坐落于國家級新區(qū)南京江北新區(qū)新材料產(chǎn)業(yè)園，是一家專業(yè)從事多肽產(chǎn) 品的研發(fā)、生產(chǎn)和銷售以及多肽技術(shù)轉(zhuǎn)讓的高新技術(shù)企業(yè)。公司秉持“誠信、嚴(yán) 謹(jǐn)、務(wù)實(shí)”的匠人精神，持續(xù)投入研發(fā)，不斷創(chuàng)新，致力于為科研工作者提供豐 富全面的多肽修飾類型和優(yōu)質(zhì)的產(chǎn)品。