Human Claudin-4 Full Length Protein (VLP)
分子別名（Synonym）
CLDN4,claudin 4
表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）
Human Claudin-4 Full Length Protein (VLP) (CL4-H52P5) is expressed from human 293 cells (HEK293). It contains AA Met 1- Val 209 (Accession # O14493-1).
Predicted N-terminus: Met
蛋白結(jié)構(gòu)（Molecular Characterization）
Virus-like particles(VLPs) are formed by self-assembly of envelop/capsid proteins from viruses. Membrane Proteins can be constituted in-situ with VLPs produced from HEK293 cell cultures. These VLPs concentrate conformationally intact membrane proteins directly on the cell surface and produce soluble, high-concentration proteins perfect for immunization and antibody screening.
The VLPs provide the display of properly folded membrane proteins in their native cellular membrane in a compact size of 100~300 nm diameter (similar to the size of most viruses) making it optimal targets for dendritic cells in vivo and surface attachment for phage display.
內(nèi)毒素（Endotoxin）
Less than 1.0 EU per μg by the LAL method / rFC method.
制劑（Formulation）
The VLPs are highly immunogenic, so the immunization strategy should be optimized (antigen dose, regimen and adjuvant).
Supplied as 0.2 μm filtered solution in PBS, Arginine, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
運(yùn)輸（Shipping）
This product is supplied and shipped with dry ice, please inquire the shipping cost.
存儲(chǔ)（Storage）
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
The product MUST be stored at -70°C or lower upon receipt;
-70°C for 12 months under sterile conditions.
背景介紹
該基因編碼的蛋白質(zhì)屬claudin家族（無(wú)內(nèi)含子基因）。claudin作為上皮細(xì)胞緊密連接的關(guān)鍵組分，是構(gòu)成細(xì)胞旁通路的整合膜蛋白，可調(diào)控溶質(zhì)及離子經(jīng)細(xì)胞旁通路的轉(zhuǎn)運(yùn)。該蛋白是產(chǎn)氣莢膜梭菌腸毒素（CPE）的高親和力受體，可能在產(chǎn)前及產(chǎn)后階段參與內(nèi)臟器官的發(fā)育與功能調(diào)控。威廉斯綜合征（一種累及多系統(tǒng)的神經(jīng)發(fā)育障礙）患者存在該基因的缺失。
關(guān)鍵字： Claudin-4;Claudin-4蛋白;Claudin-4重組蛋白;ACRO;百普賽斯;
百普賽斯集團(tuán)ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國(guó)生物科技公司，是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺(tái)型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球，橫跨亞洲、北美洲、歐洲，在中國(guó)、美國(guó)、瑞士等12個(gè)城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計(jì)服務(wù)客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長(zhǎng)期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。