Human Matriptase / ST14 Catalytic Domain Protein, Tag Free (active enzyme)
分子別名(Synonym)
Matriptase
表達(dá)區(qū)間及表達(dá)系統(tǒng)(Source)
Human Matriptase / ST14 Catalytic Domain Protein, Tag Free (MAE-H5143) is expressed from E. coli cells. It contains AA Gly 596 - Val 855 (Accession # NP_068813).
Predicted N-terminus: Met
蛋白結(jié)構(gòu)(Molecular Characterization)

This protein carries no "tag".
The protein has a calculated MW of 30.6 kDa. The protein migrates as 27-28 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method / rFC method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Supplied as 0.2 μm filtered solution in 50 mM Tris, 150 mM NaCl, 10 % Trehalose, pH7.5 with glycerol as protectant.
Contact us for customized product form or formulation.
運輸(Shipping)
This product is supplied and shipped with dry ice, please inquire the shipping cost.
存儲(Storage)
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
The product MUST be stored at -70°C or lower upon receipt;
-70°C for 3 months under sterile conditions.

背景介紹
該蛋白酶可降解細(xì)胞外基質(zhì),被認(rèn)為在乳腺癌侵襲轉(zhuǎn)移過程中發(fā)揮作用。其具有類胰蛋白酶活性特征:能夠特異性切割以精氨酸(Arg)或賴氨酸(Lys)為P1位點的合成底物。該酶通過激活絲氨酸蛋白酶prostasin(PRSS8)及加工聚絲蛋白(FLG),參與角質(zhì)形成細(xì)胞的終末分化過程;可高效水解P1位點為Arg/Lys的各類合成底物,且在P2位點傾向選擇丙氨酸(Ala)和甘氨酸(Gly)等小側(cè)鏈氨基酸。
關(guān)鍵字: Matriptase;Matriptase蛋白;Matriptase重組蛋白;ACRO;百普賽斯;
百普賽斯集團(tuán)ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。