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KRAS G12D/V/A/C 突變蛋白
  • KRAS G12D/V/A/C 突變蛋白

KRAS G12D/V/A/C 突變蛋白

價格 500
包裝 10μg
最小起訂量 10μg
發(fā)貨地 北京
更新日期 2025-08-19

產(chǎn)品詳情

中文名稱:KRAS G12D/V/A/C 突變蛋白產(chǎn)品類別: 試劑
靶點: N/A種屬: N/A
表達系統(tǒng): N/A
2025-08-19 KRAS G12D/V/A/C 突變蛋白 10μg/500RMB 500 試劑

別名 c Ki ras2 c Kirsten ras protein c-K-ras see all 功能 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. 疾病相關(guān) Defects in KRAS are a cause of acute myelogenous leukemia (AML) [MIM:601626]. AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development. Defects in KRAS are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. It is characterized by leukocytosis with tissue infiltration and in vitro hypersensitivity of myeloid progenitors to granulocyte-macrophage colony stimulating factor. Defects in KRAS are the cause of Noonan syndrome type 3 (NS3) [MIM:609942]. Noonan syndrome (NS) [MIM:163950] is a disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an estimated incidence of 1 in 1000-2500 live births. Rarely, NS is associated with juvenile myelomonocytic leukemia (JMML). NS3 inheritance is autosomal dominant. Defects in KRAS are a cause of gastric cancer (GASC) [MIM:613659]; also called gastric cancer intestinal or stomach cancer. Gastric cancer is a malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. Note=Defects in KRAS are a cause of pylocytic astrocytoma (PA). Pylocytic astrocytomas are neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Defects in KRAS are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant. Note=KRAS mutations are involved in cancer development.


關(guān)鍵字: KRAS G12D/V/A/C 突變蛋白;

公司簡介

佰諾創(chuàng)因(成都)醫(yī)藥科技有限公司利用自身細菌發(fā)酵平臺、真核細胞培養(yǎng)平臺、病毒載體培養(yǎng)平臺為客戶提供科研試劑。 在原液工藝開發(fā)板塊,公司展現(xiàn)出強勁的技術(shù)實力,搭建起了抗生素發(fā)酵技術(shù)、細菌發(fā)酵重組蛋白、原核質(zhì)粒、腺病毒、腺相關(guān)病毒、流感病毒等工藝和分析技術(shù)平臺,有力推動客戶項目快速實現(xiàn)轉(zhuǎn)化。例如在重組蛋白表達領(lǐng)域,可實現(xiàn)酵母胞內(nèi)和分泌表達、大腸桿菌胞內(nèi)可溶表達、大腸桿菌包涵表達和周質(zhì)空間表達及對應(yīng)的發(fā)酵后處理工藝;質(zhì)粒方面,產(chǎn)量可達 1g/l 以上,純度大于 95%;在病毒載體領(lǐng)域,憑借獨特的灌流工藝技術(shù)平臺,實現(xiàn)了病毒的連續(xù)化和規(guī)?;a(chǎn),其中 AAV 產(chǎn)量可達 101?vg/l 。
成立日期 2021-09-14 (5年) 注冊資本 1000萬
員工人數(shù) 10-50人 年營業(yè)額 ¥ 1000萬-5000萬
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  • 佰諾創(chuàng)因(成都)醫(yī)藥科技有限公司
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  • 公司成立:5年
  • 注冊資本:1000萬
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  • 主營產(chǎn)品:自然科學研究和試驗發(fā)展;技術(shù)服務(wù)、技術(shù)開發(fā)、技術(shù)咨詢、技術(shù)交流、技術(shù)轉(zhuǎn)讓、技術(shù)推廣;日用品銷售;專用化學產(chǎn)品銷售(不含危險化學品)化工產(chǎn)品銷售(不含許可類化工產(chǎn)品);生物基材料銷售;日用化學產(chǎn)品銷售;細胞技術(shù)研發(fā)和應(yīng)用
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